Prostate Cancer studies find advantage in daily acetaminophen and walks Brisk

POP a Tylenol and take a brisk walk for protection against prostate cancer? This is what the results of two new studies published this week suggested.

In the first study, published Monday in the journal Cancer Epidemiology, biomarkers and prevention, scientists have found that men who took a daily dose of acetaminophen (Tylenol) for five years had a 38% lower risk of developing cancer of the prostatecompared with men. In addition, daily acetaminophen has been associated with an of 51% reduced risk of developing an aggressive form of the disease. The men who took acetaminophen for less than five years saw no protective benefit.

Previous research has shown that taking aspirin or other drugs anti-inflammatory drugs (NSAIDs) every day can reduce the risk of prostate cancer. The authors believe that the same may be true of acetaminophen; While not an NSAID, it has anti-inflammatory properties.

For the study, researchers looked at data 78,485 men who participated in the longitudinal Cancer Prevention study II Nutrition cohort, answering questions on the use of food and pharmaceutical plan every two years from 1992. During the period of follow-up, there were 8,092 cases of prostate cancer - much less in the group who took acetaminophen daily for five years.

The second study, published Tuesday online research on Cancer, involved 1,455 men who had already been achieved in prostate cancer stage. Researchers at the University of California, San Francisco (UCSF) and Harvard School of Public Health, then the men from 2004 to 2009 and found that those who engaged in regular brisk walking after diagnosis were significantly less likely to see their progression of the disease.

Men who walked fast - at a rate of approximately 3 miles per hour or faster - at least three hours per week were 57% less likely to experience of the progression of the disease (including high levels of PSA)(, secondary treatment of bone metastases and prostate cancer-related deaths), compared with men who walked less and more slowly.

"The important point is the intensity of activity," Erin Richman, a postdoctoral fellow at UCSF, said in a statement. "The March must be rapid for men to experience an advantage."

Researchers have said that the effect of speed walking remains independent of age, diagnosis, type of treatment and characteristics of the disease. Average age of patients at diagnosis was 65. The findings are consistent with previous research, which suggests that physical activity can help reduce the risk of deaths from the disease in some cases of prostate cancer.

Why the association? Reports MedPage Today:

Richman and his colleagues have noted that brisk walking may reduce resistance to insulin, which reduces bioavailable,-1 (IGF1) insulin-like growth factor and increases adiponectin levels, which are all associated with the decrease in the risk of prostate cancer advanced or fatal in vitro and in vivo.

Another potential source of reduction is inflammation reduced due to low circulation of Interleukin-6, high levels of which "predicts risk of 73% increased to die of cancer of the prostate in men of normal weight."wrote the researchers.

Prostate cancer is the second leading cause of cancer death in men. According to the National Cancer Institute, men about 32,050 die of cancer of the prostate in 2010 and 217,000 new cases were diagnosed. More than 2.2 million of men to the United States with prostate cancer.

Study: 6.5% of adults active enough to work

ATLANTA - if you think that you do enough physical activity to work for you keep healthy, you are probably wrong.

Health researchers that only about 6.5 percent of American adults meet physical activity guidelines, while they work. And those that do are disproportionately Hispanic men with less than a high school diploma.

The national estimate - the first of its kind - was reported Thursday in a Centers for Disease Control and Prevention publication, morbidity and mortality Weekly Report. It is based on a national telephone survey 2007.

Somewhere between 45% and 65% of adults say they have enough outside of work to respond to the recommendations of the Government for physical activity, after previous studies.

Optimistic rock on Avastin in cancer of the ovary

ZURICH - Roche Holding AG, the world leader in Oncology medicines, struck an optimistic tone about the Outlook of its key Avastin drug approval in ovarian cancer prior to a meeting important industry next month.

Head of pharma group that Pascal Soriot told journalists Thursday he was confident Avastin will win European approval and it was also relatively optimistic for win U.S. drug support.

"In Europe... we are confident because generally in Europe you can get approval on the basis of data of good progression-free survival," Soriot said.

"In the United States, we still wait until the data are fully mature to see what the overall survival data are similar and get a good sense of the FDA response, but I must say that we have seen so far... we made relatively optimistic that we have a good chance at the United States.". Thus, "he says.

Application for Avastin, used to treat a range of tumours, has fallen over recent quarters after the drug was struck by the movements of the two sides of the Atlantic health authorities to limit its use in breast cancer.

Roche now rely on the use of the vendor of billions of dollars to treat cancer of the ovary to stimulate growth future sales and intends to submit for the approval of the United States, later this year once he gave overall survival. She has already filed for approval in Europe.

"We will demonstrate that avastin has an essential role to play in cancer of the ovary," Soriot said before the Conference of the American Society of Clinical Oncology (ASCO) earlier this month next to Chicago.

"Overall superb new data showing our pipeline progresses." We hope that the shift in the perception of Avastin, "Soriot said, referring also data on lung and skin cancer drugs that will be presented at the ASCO."

OPPORTUNITY BUSINESS

Roche will present data impact on MetMAb of lung cancer and was to produce this treatment for approval in 2014, Soriot said, adding that Roche also sought to develop the drug in other diseases such as breast cancer.

Doctors and investors will be also eyes studies on vemurafenib, a drug to treat the deadliest form of skin cancer.

Soriot, said the business opportunity of vemurafenib has been limited to the skin cancer metastatic because the smaller number of patients in this parameter, but there is more potential sales if it were to be developed in the adjuvant.

The Group has yet to decide on setting prices of treatment and has therefore not yet a peak estimate sales for it.

Drug of rock, which develops with private holding Plexxikon and ipilimumab, an experimental drug developed by the US group Bristol - Myers Squibb, are giving hope to patients who already had a few treatment options.

Soriot said there was a place for both agents and it looks vemurafenib as the first line of treatment in patients who are positive BRAF.

"Ipilimumab is a different officer." It is a compound based on the immune system to treat cancer. It is a drug which can potentially be given to all patients, while vemurafenib can only be given to patients who are positive BRAF, which is approximately 50% of patients with cancer melanoma, "Soriot said."

"It is important to keep in mind that the percentage of patients who respond really well to ipilimumab is relatively limited." These patients have a strong response, but it is a small percentage, probably 10 per cent of the patients, who meet, "he says.

Spanish poet honors overlooked hero of the Warsaw Ghetto

MADRID - largest second poetry prize of the Spain was awarded this year to a volume honoring the heroines overlooked, including Irena Sendler, who saved 2,500 Jewish children by their smuggling of the Warsaw Ghetto.

Sendler has been nominated for the Nobel Prize for peace in 2007, a year before his death. She lost to former US Vice-President Al Gore and the Intergovernmental Panel on climate change.

"It is quite clear that it could have been truly worthy recipient of the award (Nobel Prize), no question, said Fatima Frutos, winner of the poetry Kutxa Ciudad de Irun 2011 Prize, ahead of an international field of 204"

"The visibility of women must be justified, those that have been considered secondary, who had no recognition but deserve that and much more."

Frutos also recalls Artemisia Gentileschi, a prominent painter of 17th century Italian and Spanish of the 19th century writer Carolina Coronado, which is struggling to achieve recognition in the fields then dominated by men.

Moreover, it honours, among others, Carl von Weizsaecker, a nuclear physicist of the 20th century, who would later become a philosopher.

"I start with the stories and build their lyricism and poetry, to assert their verse by verse," she said. "It is not only about giving visibility to invisible women, but also to the geniuses of the 20th century whose work has yet to shake up the consciences of the 21st century."

The volume of the recipient of the "Andromeda Encadenada" (encha?né Andromeda) takes its title from the Greek mythological Princess who was chained to a rock, but figure that Frutos sees as a source of inspiration rather than a victim.

It follows his 2009 volume "De Carne y hambre" (of flesh and hunger), which won the international prize of the erotic poetry of Ateneo Guipuzcoano.

"The myth allows me to discover other women as she who, in real life, through extreme, but nevertheless came through, if not euphoric, then at least optimistic and stronger,"Frutos say.""

"Andromeda" also adopts a perspective of pan-European topical with poems dedicated to the 18th century German philosopher Novalis or lyric poet of the 19th century studied.

"Now there are many reasons to defend European culture, the European ideal, the feeling that there is no European first or second class, but that we all in this together," she said.

Frutos main inspiration as a writer was Miguel Hernandez, a Spanish poet who died in prison in 1942, during the dictatorship of Francisco Franco.

"Hernandez were inoculated we poison blessed poetry so that we can grow without rancor but with force to advance social justice," said Frutos, who works as an agent of the equality of the local government.

The price of Irun is the second valuable most award for poetry in Spain and is open to all writers in Spanish. When she collects the award on May 28, Frutos devote to his grandmother, who took her reciting poems by Hernandez, she had learned by heart, because she cannot read or write.

"She wakes without rancor with poetry." She knew how hard-hearted me with as to hands and cover me with stanzas by great writers, "she said."

"I am a poet because of it." It must be said that an illiterate woman who lived in poverty also knew how to raise an international poet laureate. ?

Skin Cancer foes declared may 27 "Don't fry day" (HealthDay)

on Friday, the beginning of the end of week Memorial Day, is also "Don ' T fry day," once for skin safety experts remind Americans about the dangers of overexposure to the Sun.

Melanoma, the potentially deadly form of skin cancer is the most common cancer in young adults in the late twenties, according to the U.S. Environmental Protection Agency (EPA) and the National Council for the prevention of Skin Cancerwho have joined forces to offer advice to save lives on the caution in the Sun. The main cause of skin cancer: overexposure to harmful ultraviolet (UV).

"Many people still don't realize that exposure to the Sun without protection can lead to cancer of the skin and other health problems," said Gina McCarthy, agency Administrator assistant for the EPA Office of Air and radiation, in a press release. "Simple steps, such as using a sunscreen, wear sunglasses or a hat, can protect us and our families, while still enjoying the outdoors."

Skin cancer, the most common type of cancer in the United States, affects more than 2 million U.S. dollars - every year more breast cancer, prostate, lung and colon combined, said the EPA. Every hour, an American dies of cancer of the skin, the Agency noted.

Although the UV rays are dangerous year round, the risks are greatest in the summer months when people spend more time outdoors, McCarthy said.

To limit exposure to harmful UV rays, expert proposes to you:

Cover you. One of the most effective ways to reduce the exposure to the harmful rays of the Sun is to wear a shirt, hat and sunglasses and Sunscreen SPF 15 +. Find a shady place. It is best to stay out of direct light from the Sun during peak hours, from 10 h to 16 h being aware of the UV index. Get involved in outdoor activities, check the UV index to identify the time more risky for overexposure to the Sun.

Charity pulls smart stunt on pregnancy Bruni rumours (Reuters)

DEAUVILLE, France (Reuters) - at a glance of smart advertising, charity leader traded on rumours of possible pregnancy of Carla Bruni-Sarkozy to try to save the lives of babies in developing countries.

Before the Summit of the G8 rich countries who made the cut infant mortality a major theme in recent years, World Vision activists delivered a basket to the first lady of France with a kit of easily available in France delivery.

"What are simple products that any woman in Europe or North America can obtain at the pharmacy, but are inaccessible for many women in the developing world", Geraldine Ryerson-Cruz of the charity World Vision of Britain told Reuters.

Ryerson-Cruz said his charity is fighting to try to ensure that children around the world have the same chance of survival than the "first baby" French would have.

The French presidential palace has confirmed the pregnancy of Bruni, but the father of the President of the last week, Nicolas Sarkozy told a German newspaper that Bruni expects a child.

In the historic Villa Strassburger, World Vision activists delivered a basket with vitamins for pregnant women, a kit of safe delivery and hygiene supplies.

The basket was alcohol, surgical gloves, a razor blade for cutting the umbilical cord and sterilization baby care products.

Friday, Bruni will host first ladies of African nations participating in the Summit.

"As a French woman, Carla Bruni-Sarkozy is 150 times more likely to survive pregnancy and childbirth than a woman in the former French colony, Chad," Ryerson-Cruz said in an interview.

Ryerson-Cruz said that baby of the Bruni is also 52 times more likely to survive until the age of five as a baby with Chad, which has one of the worst years of child mortality in the world.

Sarkozy welcomed the leaders of the eight richest countries of the world to the posh seaside seaside Deauville Thursday and Friday. Several North Africa and sub-Saharan African heads of State will also attend the meeting.

Ryerson-Cruz said that estimates of Global Vision that mainly thanks to the initiatives of the g-8 in recent years the number of preventable deaths by the vaccination of children around the world declined approximately $ 4 million to approximately 8.1 million in 2010, 12.4 million in 1990.

Childhood treatments related to gastrointestinal problems

 children who are treated successfully for cancer are more at risk of developing severe mild gastrointestinal problems on the road, a new study concludes.

Researchers at the University of California, San Francisco analyzed the self-reported gastrointestinal (GI) problems of 14,358 patients surviving at least five years after the treatment of cancers such as lymphoma, leukemia, tumors of the brain or bone tumours.

More than 40 per cent have experienced some type of problem of IM - including ulcers, the disease of the esophagus, indigestion, polyps, chronic diarrhea, colitis, gallstones and jaundice - in two decades of their treatment, researchers have discovered.

In addition, people with cancer at a later age and who had to undergo a more rigorous treatment (chemotherapy, radiotherapy, surgery) were more likely to experience problems IM long term, according to the study of the may issue of Gastroenterology.

About one in 500 young adults in the United States is a survivor of childhood cancer, the study authors noted in a press release UCSF.

"While doctors continue to learn more about pediatric cancer and its treatment long term consequences, it is essential that we provide care of comprehensive follow-up that adequately addresses the complications can meet the cancer survivors.""," study lead author Dr. Robert Goldsby, specialist of pediatric cancer hospital for children of Benioff UCSF and Director of the UCSF Cancer of childhood survivors program, said in the press release.

"These are serious issues that can have a real impact on the quality of life of the person," added Goldsby.