Saturday, April 30, 2011

Multiple pregnancies can high risk of obesity, diabetes: animal study (HealthDay)

 multiple pregnancies can increase the risk of obesity, diabetes and the build-up of plaque in arteries, suggests new research in mice.


Scientists from the University of Cincinnati and colleagues studied the mouse towards the end of gestation in both their first or fourth pregnancy. Those of their fourth pregnancy had severe glucose intolerance and adipose tissue excess, while those in their first pregnancy had no glucose intolerance and had less fat.


In addition, the adipose tissue of mice in their fourth pregnancy had significantly increased in several chemicals that cause inflammation called cytokines and accumulation of white blood cells called macrophages inflammation.


Cytokine changes repeated during pregnancy can cause residual inflammation that affects heart health, according to the study of.


If such changes occur also in humans, women who have multiple pregnancies can be at an increased risk of accumulation of plaque in arteries, obesity and diabetes, the researchers concluded.


The study was to be presented Friday to the American Heart Association arteriosclerosis, thrombosis and vascular biology 2011 scientific sessions in Chicago.


Because this study was presented at a medical meeting, the data and conclusions should be considered preliminary until published in a refereed journal.

Children with diabetes comes from heavy Price Tag (HealthDay)

(Friday, April 29, HealthDay News) - the medical expenses for children and adolescents with diabetes are six times higher than for other young people in the United States, a new study finds.

Researchers from U.S. Centers for Disease Control and Prevention examined health insurance claims made in 2007 to nearly 50,000 youth aged 19 and younger, including 8,226 with diabetes.

Annual fees for young people with diabetes were $9,061, compared to $1 468 for those without diabetes. Drugs and ambulatory care represented a large part of the additional medical expenses.

The highest medical costs were for young people with diabetes who had need of insulin, which included all those who are suffering from type 1 diabetes and some type 2 diabetics. The annual medical expenses for those receiving insulin were $9,333, compared to $5,683 for young people with diabetes who did not insulin.

Medical expenses for all Americans with diabetes, with most adults are 2.3 times higher than those without diabetes, according to CDC 2011 National Diabetes Fact Sheet.

The difference of the medical costs of diabetes may be higher among young adults due to the higher of drugs, visits to specialists and medical supplies such as syringes for insulin and glucose testing strips, according to researchers.

They noted that 92% of young diabetics required insulin, compared to 26% of adult patients with diabetes.

The study appears in the may issue of the journal Diabetes Care.

More information

The American Diabetes Association has more on children and diabetes.

New clues how Gastric Bypass Surgery fighting diabetes (HealthDay)


 gastric bypass surgery has been known to improve glycemic control, often send people with diabetes type 2 in remission, but experts have long wondered exactly how this occurs.


Now, a new study provides some clues.


Movement of amino acids associated with insulin resistance significantly decrease of those who have the bypass, the researchers found. They compared the 10 obese diabetic who had surgery with 11 who lost weight through dieting.


"Something happens after gastric bypass happens not long after weight loss induced by the diet,", said Dr. Blandine Laferrere, Associate Professor of medicine at St. Luke-Roosevelt Hospital Center and Columbia University, New York.


The study is published in the issue April 27 translational Medical Science.


The surgery, which reduces the stomach of the size of a small pocket, also modifies the junction between the stomach and small intestine. It leads to a dramatic reduction in the level of amino acids that have been associated with diabetes in circulation.


"The fact that gastric bypass causes the remission of diabetes in the majority of the patients is not new," said Laferrere. According to information from bottom in the study, 50-80% of cases of diabetes pass in remission after surgery.


What doctors have tried to understand, she said, is why the bypass is so good to make diabetes to disappear. "Diabetes improves almost immediately, before that occurs a significant amount of weight loss," she said. "Which highlights that it is something other than weight loss."


In the new study, researchers assessed biochemical compounds involved in metabolic reactions among participants. Each group had lost about 20 pounds.


The researchers found that patients of bypass had much lower amino acid known as branched amino acid and acid amino phenylalanine and tyrosine.


"These changes in amino acids could be involved in the mechanism of diabetes after gastric bypass," said Laferrere.


Experts know that amino acids are related to resistance to insulin in part by studies on animals, she said. "If complete you the feeding of rats with amino acids branched, you can induce insulin resistance," she explained.


However, Laferrere said, the finding does not mean all obese diabetics should choose surgery on a diet. Surgery is very intrusive, she noted, and not everyone is a candidate.


The results are interesting, she says, but it is too early for applying in the treatment of diabetes. Finally, she added, when experts understand more about how the surgery affects the amino acids, it may be possible to apply the findings to develop better treatments for diabetes or less invasive surgery.


The new study adds weight to other research finding a link between the decline in the branched amino acids and the decline in the resistance, insulin, said Dr. Thomas j. Wang, Professor Associate Professor of medicine at Harvard Medical School and a co-author of the perspective that accompany the study.


"It is known that gastric bypass quickly reverses resistance to insulin, which is one of the main biochemical abnormalities that precedes diabetes," said Wang.


"This study really helps to confirm this hypothesis that branched amino acid down more in people who have Bariatric Surgery," he said. While he supports the idea that there is a link between the reduction in amino acids and decrease insulin resistance, it does not prove cause and effect, Wang added.


"It shows people who attain Bariatric Surgery have a greater fall in their branched chain amino acids." Which has not yet been proven is whether if this reduction in the branched amino acids is the reason for which their insulin resistance decreased, "he noted."

Wang and his co-author, Dr. Robert Gerszten, are co-inventors on patent applications related to predictors of metabolite of diabetes.

Wang and Gerszten also noted that the number of obese diabetic type 2 was $ 171 million in the world in 2000. By 2030, this number will double. Therefore, they have written, if a detailed understanding of the role of amino acids in diabetes it would be useful.




Early surgery boosts results for babies with cleft palate (HealthDay)

prenatal diagnosis, early surgery and care well co-ordinated by a team of specialists are vital for children born with cleft lip or cleft, experts say.


Cleft lip or palate - occurring in the first trimester of pregnancy when the roof of the mouth does not fuse properly - affects more than 7 000 babies born each year in the United States and is most often defect of birth.


Prenatal ultrasound may detect the majority of cases. Once a diagnosis is made, doctors should counsel parents to give them time to prepare emotionally before the birth of the baby, experts say. Physicians and parents also need to develop a treatment plan, according to the Dr. Richard Redett, plastic pediatric and reconstructive surgeon and Associate Director of the clinic of slot & Craniofacial Centre at Johns Hopkins children's.


He noted that research has shown that early surgery helps ensure the development of the word. Surgery is most effective if made before the baby is one year.


Postoperative treatment should include specialists from the ear-nose-throat, speech therapists, Pediatric Orthodontists and psychologists said Redett.


He and his colleagues offered a few tips to prevent cleft lip/palate:

Planning become pregnant should take 400 micrograms of folic acid per day.Pregnant women should not smoke and should avoid second-hand smoke.Pregnant women also need to talk to their physicians any prescription or over-the-counter drugs, they are taking or planning to take, since some medications can cause or increase the risk of birth defects.A family history of cleft palate patients should talk with their physician procedure genetics.

Simple checklist can identify signs of autism by age 1 (AP)

WASHINGTON - a simple checklist parents fill in the waiting room may help doctors to screen a day for warning signs of autism as early as the first anniversary of the baby.

San Diego pediatricians tested the tool with more than 10,000 babies to their 1-year exams, looking for items such as how toddlers babble, gesticulating and interact with others.

The research, being published Thursday, is a first step in the search for autism screening earlier. It is not ready for everyday use, as more work is needed to verify the accuracy. But it can also be useful to find babies at risk more to study what are the causes of the disorder of development.

"There are subtle signs of autism in a year if you just look for them, said neuroscientist Karen Pierce of the University of California, San Diego, who led the study." Just leave these children detected early and treated early. ?

Recent data suggest about 1,100 children U.S. has a shape any of autism, which ranges from mild to severe behaviour problems, socialization and communication. The American Academy of Pediatrics Urges already tours of screening for autism in the regular medical doctor at the age of 18 months and 24 months. However, a 2009 study found that children on average do not diagnosed that they're 5.

Experts say early therapy may reduce the severity of autism, even if they don't know exactly what will be best. "The sooner you start, better it is," said Dr. Lisa Gilotty of the National Institute of Mental Health, which contributed to funding the study.

Hence the interest of younger screening.

"It is very, to think that we are able to identify the children with autism present from the beginning, exciting work," said Dr. Susan Hyman, of the University of Rochester and a specialist in autism paediatric academy, which was not involved in the new study.

But, she warned, it is not clear how best to do so: "I think screening for Autism at 12 months is ready for the first time.".

Study of Thursday uses a 24-question written in terms easy to understand that parents may respond in five minutes approximately. It was developed a few years ago to detect wider sign language or developmental delay. Pierce signed 137 pediatricians to use the questionnaire in the balance sheet of each year and return the baby that is not to further testing. These young people have re-evaluated every six months at the age of 3, where a diagnosis could be certain.

Of currently selected babies, 184 were sent for further testing followed - and finally 32 have been diagnosed with autism, Pierce said Thursday in the journal of Pediatrics.

Which is consistent with expected that young detection rates; Hyman of Rochester said that some forms of autism become apparent until the age of 2 or even later.

Many other children have been diagnosed with language delay or some other problems of development, so that ultimately the screening predict with accuracy a problem some 75 per cent of these children, calculated Pierce. But there is 1 to 4, with no false alarm problem.

The children began treatment to approximately 19 months. Pierce program also MRI and other tests in broader research in the biological basis of autism studies now limited by the number of babies being identified as at risk when they are young.

A large puzzle: only a fraction of 1,318 total babies with no initial screening has received follow-up. The study could not say how much this gap was registration error, or if doctors or parents worried enough to follow immediately, or if the families went elsewhere.

Yet the study shows early screening is feasible in the hectic daily regular pediatricians offices. This is important because scientists now develop various screening tests, said Geraldine Dawson, Officer Chief science of Autism Speaks, whose work has co-financed.

Pierce said other cities should consider screening - but doctors must first know where to send the families for follow-up testing. That can cost several thousand dollars, and the programs of the State for a free assessment of children at risk can have waiting lists.

For now, what should worry parents? Top concerns of Pierce.

_Lack of what she calls "shared attention." 1 Year of age, babies should try to "pull your attention in their world," pointing to a bird and look to see if you look, for example, or to provide you with a toy, she said.

_Lack of shared enjoyment, where a baby can smile to mom, but not intervene if other people try peek-a-boo.

The behaviour of _Repetitive as a wheel of spinning, instead of playing with the toy.

Language delays are worrying if they accompany other signs of problem, she said: "if they wave and they point, it is a good sign the brain is characterized to be ready to take the floor."

Low levels of vitamin d linked to obesity in children (HealthDay)

a vitamin d deficiency is common among American children and related to obesity and the different types of fat distribution in young whites and blacks, shows new research.


Vitamin d is found in some foods, but humans synthesize most of the nutrients that they need the action of the Sun on exposed skin. Supplements may also stimulate vitamin d levels.


In the study, researchers checked the levels of vitamin d in 237 obese healthy and non-obese black and white children, aged 8 to 18 years. They found that most of them were deficient in vitamin d. low levels of vitamin d are associated with the index higher body mass and levels of fat and lower levels of HDL "good" (HDL) cholesterol.


Among those who have a vitamin D deficiency, white children were more likely to have higher levels of fat between their internal organs (visceral), while black children was more likely to have high levels of fat just under the skin (adipose subcutaneous)investigators found.


The study is published in the may issue of the Journal of Clinical Endocrinology & metabolism.


"Vitamin d deficiency is endemic in American youth, and it is suggested that low levels of vitamin d plays a role in increasing rates of type 2 diabetes adults." It is possible that may even be true for young people with diabetes type, of the University of Pittsburgh 2, lead author Dr. Silva Arslanian, said in a press release of the endocrine society.


"More therapeutic interventions to correct the high levels of vitamin d deficiency among youth, benefits of vitamin d optimization on fat, lipid profile [blood lipids] levels and the risk of diabetes type 2 must be explored""Arslanian added."

Dispose of unused medicines Saturday (HealthDay)

(Friday, April 29, HealthDay News) — Americans can transform into unused drugs to more than 4,700 sites nationwide Saturday in National Prescription Drug recovery day of U.S. Drug Enforcement Administration.

The free event, held from 10 a.m. to 2 p.m., local time, allows people to decide safely expired prescription drugs, not used and not desired that could be stolen and misused if left in a medicine cabinet House.

Collection sites by going to the site Web of DEA (www.dea.gov) and clicking on the banner "got drugs?" can be found. You can search for your site collection closet by postal code, city or County.

More Americans abuse prescription than cocaine, hallucinogenic drugs and heroin combined, according to the national survey of substance abuse and health 2009. Studies show that drugs are often obtained from family and friends.

Last year, more than 242,000 pounds--121 tons - of drugs were collected to 4 100 sites by the Government, community, public health and partners of the law, according to a DEA press release.

"Not only the overwhelming public response to first nationwide resumption, the DEA last fall event removes potentially dangerous drug houses, but has been an unprecedented opportunity to inform everyone on the growing problem of prescription drug abuse""," DEA Administrator Michele Leonhart has stated in a press release agency.

"Studies have shown that, for many, prescription drugs are the first drugs that they abuse and too often they are not the last." This is why we are committed to helping the Americans to protect their homes by ridding their expired medicine cabinets, not used and unwanted medicines, ", she added."

More information

The U.S. Food and Drug Administration has more on the safe disposal of drugs.

Thyroid drugs may raise risk of Fracture in elderly (HealthDay)

many seniors may be at increased risk of fractures because they are "excessive" doses of drugs used to treat thyroid gland problems, a new study said.


The results suggest that the objectives of the treatment must be modified in elderly patients with thyroid gland problems and that it is essential in the advanced age of regular dose of thyroid medication monitoring, researchers said.


Reports in the online edition of April 28 of the BMJ, they examined the connection between fractures and levothyroxine, a synthetic form of thyroid hormone, which is widely used to treat a lazy of the thyroid gland (hypothyroidism).


Many patients with hypothyroidism is diagnosed in early or middle adulthood. Even if their processing requirements change with age, many patients still on the same dose of drug. This can lead to excess of thyroid hormone, which increases the risk of fractures, especially among older women, said the authors of the study.


They analyzed data more from 213,500 patients aged 70 years or more, in the province of Ontario, the Canada, who completed at least a levothyroxine order between April 1, 2002 and March 31, 2007. During the study period, more than 22,000 (10.4%) patients suffered at least a fracture.


Past and current users (who had arrested drug 15 to 180 days before the start of the study) had a significantly higher than the "remote" users risk of fracture (which had ceased the use of the drug more than 180 days before the start of the study).


Among current users, those who have high or average drug doses were much more likely to suffer fractures than those taking a low dose.


"Our results provide evidence that levothyroxine treatment may increase the risk of fractures of frailty in the elderly even at conventional doses, suggesting that closer monitoring and modification of the objectives of the treatment may be justified in this vulnerable population""," concluded Lorraine Lipscombe, researcher at the Institute for research of College Torontoet women colleagues.


An expert was not surprised by the findings.


"It has long been known that high or excessive use of levothyroxine dose predispose [persons] to an increase of osteoporosis and fracture risk," said Dr. Irwin Klein, Director of the unit of the thyroid and Associate Chairman of the Department of medicine at North Shore-LIJ to ManhassetN.Y health system. "more, this study confirms this conclusion in a population of women who are inherently at risk for this occurrence."


Klein also noted that the study highlights the need for preventive action.


"As the authors conclude, it is important to monitor the blood tests of thyroid - especially the levels of TSH - to prevent this potential undesirable burden," he said.

DNA tests link South of leprosy cases of Armadillo (AP)

LOS ANGELES--with some genetic research, scientists have rights a likely culprit in the spread of leprosy in the South of the United States: nine-banded Armadillo.


DNA tests show a match in the strain of leprosy among some patients and these prehistoric creatures for research - a scientific connection was suspected but until now could not identify.


"Now, we have the link," said James Krahenbuhl, who runs a program of leprosy of Government that led the new study.


Only about 150 cases of leprosy occur each year in the United States, mainly among travellers in places like the India, the Brazil and Angola where it is more common. The risk of contracting leprosy of an Armadillo is low because most people which is presentations will fall ill with the ancient plague, known as Hansen's disease medically and curable treatment so quickly.


Armadillos are mammals with very few bacteria that cause disease sometimes disfiguring, appearing first as a unusual lumpy skin lesion.


Researchers at programs in Baton Rouge, Louisiana) National Hansen's disease, has led an international team of scientists who published their results in New England Journal of Medicine Thursday. They believe that it requires frequent handling of armadillos or eat their meat for leprosy to spread.


DNA samples were taken from 33 wild armadillos in Arkansas, Alabama, Louisiana, Mississippi and Texas, where they are sometimes called "hillbilly humps" because they are often crushed by cars.


Scientists also took some skin biopsies of 50 patients with leprosy being treated at a clinic in Baton Rouge. Three-quarters had never been foreign exposure, but lived in the southern States, where they could have been exposed to and armadillos.


An analysis found that samples of patients and armadillos were genetically similar to each other and were different strains of leprosy found elsewhere in the world. The single strain was found in 28 armadillos and 25 patients.


15 Patients for which researchers had information, seven said they had no contact with the armadillos. eight said that they did, including one who systematically hunted and ate the.


While labour document not for a direct transmission from animal to human, "the evidence is pretty convincing that sometimes,", said Dr. Brian Currie, an expert in infectious diseases at the Montefiore Medical Center in New York, which had no role in the study.


Leprosy remains a problem in tropical hot spots in the world with about 250 000 new cases of infection reported each year. As tuberculosis, it can remain dormant for years before attacking the skin and nerves.


While the disease is contagious, it is difficult to catch. People most at risk are family members who are constantly in contact with a person not processed. Leprosy cannot be spread through casual contact such as communication protocol, or sexual intercourse.


The disease has long been poorly understood and those who acquired were often avoided it. Fear of spreading has led some countries to approximately 40 people. False stories on the fingers and toes fall added to stigma.


The disease is curable with rapid treatment of complications before antibiotics in. The drugs usually kill bacteria in the days and make it non-contagious. It takes usually a year or two to completely erase the germ of the body.


Untreated, leprosy can cause nerve damage if serious people to lose feeling in their fingers and toes, leading to the deformation and disability.


While the germ attacks skin, hands and feet of humans, it tends to infect the liver, the spleen and the lymph node of armadillos.


"Let the animals," informed the principal investigator Richard Truman Hansen National disease programs.

"I would not be toying with armadillos,", said Dr. Warwick Britton, of the University of Sydney, Australia, who had no connection with the study.

For Ymelda Beauchamp, how it is infected in decades remains a mystery.

When she was 15 years old, she noticed lumps on his skin and felt numbness in hands and feet. His left hand began levies to the Interior.

After graduating from high school, she decided to ask a former sugar plantation Carville (Louisiana), which has been transformed into a clinic for patients with leprosy treatment. He y once when the pain was so excruciating, she said that she did not want to wake up.

Today, the 59 year-old Beauchamp is free from disease and works as a defender with the Missions of American leprosy, a group of Christian who contributed to funding the study with other groups in support of leprosy and the National Institutes of Health.

Still, it has no feeling in his hands and his feet and has be careful do not burn or cut itself in baking.

"It is not difficult, but it is not easy," said. "You you get enough for it."











Most of the survivors of Cancer would sacrifice breast healthy again: study (HealthDay)

despite concerns about the appearance, the few survivors of breast cancer who has opted for a double mastectomy as precautionary measure regretted their decision decades later, a new study concludes.


Researchers at the Mayo Clinic in Rochester, Minnesota, interviewed hundreds of women who have sacrificed a healthy breast in the hope of avoiding another cancer. Twenty years after their surgery, 97 per cent said that they make the same decision once more.


"The real question is, how they feel you long term?" said the researcher Dr. Judy v. Boughey, breast surgeon and associate professor of surgery. "I want my patients to do what they will be satisfied in 10 or 20 years."


Previous research found that women who had undergone a prophylactic double mastectomy were satisfied with their decision shortly after the surgery. This new study shows that those who are "satisfied" that decision is still many years after, said Boughey.


The findings were presented Friday at the annual meeting of the American Society of Breast Surgeons in Washington, D.C. presented research at meetings is considered preliminary until published in a refereed journal.


With improved today breast reconstruction techniques, women are likely to "be even happier with the results" that they were in recent decades, noted Dr. Stephanie Bernik, Chief of surgical oncology at Lenox Hill Hospital in New Yorkwho is familiar with the findings.


Breast cancer affects approximately one in eight U.S. women, according to the National Cancer Institute. Almost 90 per cent will survive five years or more, according to the Agency.


Surgical treatments include a Lumpectomy (excision of the tumour and surrounding tissue), mastectomy (removal of diseased breast) or double mastectomy (removal of the two breasts). Double prophylactic mastectomy does not guarantee that the cancer will not recur.


Auxiliary treatment may include radiation, chemotherapy or hormone therapy, said Boughey.


The study, women with a cancer of the breast and a healthy breast removed between 1960 and 1993 were requested 10 years later if they were satisfied with their choice. They were also asked if they would the same decision once more.


After another 10 years, the majority have been surveyed once more. Complete results are available for 269 women.


In the original investigation, 86% said they were satisfied with their decision and 95% said that they would repeat the procedure if they had again. After 20 years, 90% are satisfied with their decision and 97% said they would repeat.


However, approximately 30% in the two periods of time said that they have suffered negative body image and almost a quarter said their sense of femininity and sex have been affected. These effects increase with time, the results showed.


Experts say that the Outlook for women undergoing mastectomy today are much improved in 20 years. "We have procedures that they did not even when women in this study have their surgeries", said Bernik.


For example, breast reconstruction now often accompanies the cancer surgery. The important thing is for women to put an end to the decision, said Bernik.


"We push it [double mastectomy]," she said. Often, a young woman were children, treat them and then decide to have the deleted second chest, she noted.


According to Bernik, approximately 10% of breast cancers are caused by genetic mutations, and women who have family members already diagnosed breast cancer are at higher risk if cancer is genetically influenced.


Other risk factors for breast cancer are age or long exposure to estrogens, which occurs when menstruation begins at an early age and continues beyond 50, said Boughey. Women who give birth to first child later in life are also at higher risk, she noted. Men can also develop breast cancer, but it is rare.

Cancer patients do better these days that even five or ten years earlier, said Boughey.



Get the image perfect for a party

real test of success comes after the party - when pictures of you and your date start appearing everywhere.A spray tan can give you a nice glow and even out your skin toneUsing over-the-counter whitening products can brighten your smileFollow a diet high in vegetables and fruit and low in sodium to get rid of bloating

Sure, the event is nice, with its twinkling lights and slow-dance butterflies. But the real test of success comes after the party - when pictures of you and your friends start appearing everywhere.


You're uploaded to Facebook. You're e-mailed to your aunts in Seattle. You're rotating across your mother's desktop background in a perpetual stream of twisted hair and pink Brocade.


"this generation of teens is so obsessed with taking pictures," Seventeen magazine beauty director Yesenia Almonte said. "They're spending eight hours a day just socializing through media."


With less than a few weeks (or days) until the big night, high school teens across the country are preparing for prom. Those of us a little, ahem, older than 17, are worried about upcoming weddings, graduation celebrations and/or family reunions.


So how can you avoid being added to the latest awkward family Photos even?


Follow these tips from our beauty expert and you'll be picture perfect in no time.


Consider a spray tan


"Spray tanning is such a great thing," said Almonte. "It gives you a nice glow and evens out your skin tone." It's infinitely better than damaging skin cells by lying out in the sun or baking in a tanning bed.


DHA, the active ingredient in modern day tanning solutions, works with the proteins in the top layer of your skin to turn it golden brown.


Since your upper epidermis is made up of dead cells, they aren't harmed in the process and the chemicals won't be absorbed into your body because they will eventually shed off with the dead skin. The FDA recommends spraying in a well-ventilated area and wearing a mask to avoid inhaling DHA.


Many shows offer spray tanning, but there are also mobile experts who will come to your home. You'll get personalized service, and most importantly, a customized solution, said Mandie Price, founder of the Mobile Tanning Association and owner of Gold not Delicious Tans in Texas.


"One shot for everybody doesn't work," Price said. "That's why spray tanning has that stigma of ' please don 't turn orange me.'" "The trick is to find a technician who will apply the proper solution for your skin type to avoid that 'snookie tan' that we all fear."


If you are going to a show, make sure to ask whether they offer varying strengths of solution. Pick one with 8% DHA if you're unsure - Price says it looks good on most skin tones. And look for a company that's using the newer, faster HVLP sprayers.


Most spray tans fade away in seven days. Get it done two days before your event if you're wearing a light-colored dress; one day before is fine if it's a darker color. For more tips on spray tanning, check out Price's client dos and don'ts list.


Whiten your teeth


No need to make an appointment with your dentist. A ton of teeth whitening products are on the market and almost any of them will produce results with some time, Almonte said.


The American Dental Association says whitening products work in one of two ways, either bleaching the tooth to change its color or by using physical reactions to remove surface stains.


Whitening strips work well in just a few days by bleaching surface and set in stains similar to a professional service.


Or use a dental association-approved whitening mouth rinse and toothpaste. Toothpastes contain elements that help scrub off polishing surface strains over time. Chew some whitening gum on the side and you'll notice a significant change in as little as two weeks.


"A brighter smile just sort of lights up your face - it makes your skin look better, your eyes look brighter," said Almonte.


Be aware that using whitening products with hydrogen or carbamide peroxide (commonly found in whitening strips or trays) can lead to tooth sensitivity. Follow the instructions on the package regarding the length of time you leave them there. If you experience discomfort, remove the strips immediately.


Now say cheese!


Clear up your skin


There's nothing worse than waking up before the big day with a supersized zit on your forehead or finding a patch of acne on your back when you had planned to go strapless.


Your plan of attack depends on how much time you've got before the party, Almonte said.


"If you already break out and you want to start a (cleansing) regimen a few weeks before, that's great, but know that it takes a few weeks for a regimen to kick in."


This is true for bacne too. Use a salicylic acid body wash and you should see things clear up in a couple of weeks.


If you get a zit three or four days before the party, you have a good chance of getting rid of it with a daily salicylic acid face wash and a benzoyl peroxide topical cream.


Does stress have one popping out the day before? Call a dermatologist and get the pesky pimple injected with cortisone. The shot will shrink it down so you can cover it with concealer and foundation (use both, Almonte says) later.


Unfortunately, if it's the day of, you're out of options. Put some ice on it to reduce the swelling and give the photographer your "good side."


Lose the bloating


First let us note that there's no way to safely drop a few pounds in a short amount of time, and wanting to do so for any one opportunity highlights an underlying body image issue.


That said - we've all been there. But the best ways to get rid of that extra water weight before a party don't involve skipping meals, laxative taking or eating grapefruit for a week.


"Diet pills and diuretics don't result in any real body weight loss," said Kendrin Sonneville, a registered dietitian and researcher who specializes in adolescent nutrition. "using these products can lead to dehydration and electrolyte imbalance, which can affect your heartbeat and have serious health consequences."


Skipping meals, even snacks, also tends to backfire. "your metabolism burns most efficiently when you eat consistently."

So eat. Eat foods high in water content such as fruits and vegetables and low in sodium, like lean meats. Avoid processed foods, and snack every three to four hours. Follow this "diet" and you'll have the energy required to deal with mom's shutterbug tendencies AND dance the night away.

Zytiga approved for Cancer Advanced Prostate (HealthDay)

 Zytiga (abiraterone acetate), used in combination with the steroid prednisone, has been approved for treatment of advanced prostate cancer, the U.S. Food and Drug Administration said in a press release.


The growth of cancerous prostate tumors is fed by the male hormone testosterone, and the new combination drug blocks a protein that plays a key role in the body of testosterone production, the Agency said.


Zytiga has been evaluated in clinical studies involving some 1,195 men advanced with tumor prostate cancer continued to grow despite chemotherapy. The men who received the combination Zytiga/prednisone lived an average of 14.8 months, compared to 10.9 months men who took a placebo, the FDA said.


The adverse effects common to the combination of drugs included joint discomfort, low blood potassium, retention, muscle discomfort, puffs of heat, diarrhea, urinary tract infections, cough, high blood pressure, heart rate, increased urination anomalies frequentstomach aches and upper respiratory tract infections.


Zytiga is produced by Centocor Ortho Biotech, based in Horsham, PA.

Seth Rogen: Alzheimer's disease is "brutal".

 Seth Rogen can be known for starring in a few torrid comedies, but there is a problem, it is not taken lightly: Alzheimer's disease.


The condition crashed near the House by his future mother-in-law, which is only 59 and already has for several years. And now Rogen, who has no family history of the disease, became passionate support of the family of his fiancée and spread awareness of Alzheimer's disease.


"I think that until you can see directly, it is difficult to conceive in a brutal manner, it is," Rogen told CNN on Tuesday. "Until I saw it, you find heartbreaking type of how it may be.".


Rogen and his fiancée, Lauren Miller, previously talk with Larry King for "a Larry King special, the unthinkable: epidemic of Alzheimer's disease," which is broadcast Sundays at 8 p.m. (et).


Their story is that an example of the effects of emotional stress training introduced the disease.


"I just try to be as close as possible, also emotionally available as possible," Rogen said Tuesday CNN.


Approximately 5.4 million people in the United States suffer from Alzheimer's disease, according to the Alzheimer's Association. In the century, 16 million people should have the condition.


3 stages of Alzheimer's disease diagnosis brought


But the effect is even larger than just patients. There are caregivers non-paid nearly $ 15 million, not to mention the rest of the family and friends that tirelessly help even if no prevention, treatment or cure has been found. The disease is fatal. The average disease duration is four to eight years, although some people can live with it for 20 years.


And caregivers are providing 17 billion hours of care each year, unpaid for an annual cost of 206 billion, according to the most recent report of the Association Alzheimer.


Shriver: Nation a woman takes on Alzheimer's disease


Alzheimer's is the sixth cause of death to the United States, and one in eight Americans aged has it. The first symptoms often include problems to remember names and recent events. As the disease progresses, patient confusion was worse still, and he or she may have difficulty with basic functions such as walking, talking and swallowing. Some patients become violent, making even more difficult caregiving.


In view of the family history of bride of Rogen, the case seemed obvious when the mother of Miller began to show symptoms. Two grandparents of Miller had Alzheimer's disease. his grandfather has shown signs in his fifties. Mother of Miller was 55 years old when the family discovered that she had Alzheimer's disease.


When symptoms begin before age 65


"It would be remembered a story that I said to him, forgetting that she had spoken with someone. So it was quite clear to us what was going on, Miller told King.


Most Alzheimer's patients are aged 65 or more, but the condition can affect much earlier. Having a parent, brother or sister with the condition raises your risk of developing it yourself; both parents first degree would raise the risk. There is also a particular gene that ups the chance you will get it. None of these factors is designed, so it is difficult to predict with certainty which will develop the disease.


"The greatest misunderstanding is that it is this disease of old-people wave arrives for elderly people," says Rogen.


Rogen, who has known Miller for six years, also noted decline of his mother. It was a lot of difficulty carrying on conversations and seems if worsen even after only a few months had gone by. She had the wrong more access to words, he told King.


Medicine ineffective Alzheimer's disease for mild cases


Father Miller retired to take care of it at home. He cooks, cleans and makes his hair every morning. Miller said her mother yet known, but she is fighting with the father of Miller.


"It takes her shopping if she needs something to wear." And my father does not like shopping, Miller a. "I do not think that you are 62 years old and, you know, one day of his retirement think that you will take care of your spouse with Alzheimer's disease.


Mother of Miller does not lose his temper, but she gets so confused that she does not know why people are trying to help, the couple told King. Rogen told CNN that the mother of Miller seem to get particularly disoriented after a trip to the coast is the West Coast, so Rogen and Miller are trying to go to him instead.


Substantially with your relationship with a change of the person that he or she forgets events, information and even your name can be an emotional shock, says Beth Kallmyer, Director of customer service and information to the Alzheimer's Association.


Some people feel that they know be how to interact with an ad, and withdraw because they do not want to see their friend or relative in such a State.


But Rogen feels uncomfortable with the mother of Miller and described it as "easy to be around."


"I understand that it passes through something that I can't imagine even what it is like passing by", said Rogen.


Provide emotional support for Miller, he has also given financial assistance to his family for medical and other expenses.


Caregivers must learn about the disease and establish a support network, Kallmyer said.


Leeza Gibbons advice to caregivers: breathe, believe, receive


"You cannot do it alone." It takes too much of you. "You want to build a team of care about the disease, so that you know what to expect, she said."


Persons in a position to Rogen, who want to help but are not the primary caregiver, should know the person nearest to the patient which makes the patient happy and what makes him or her paymentKallmyer said. They should also ask directly the caregiver must more.


Generally, the caregivers have just need a break, she said. Often, something useful for a family dealing with this disease is to intervene and do something with the Alzheimer's patient, while care staff deals with issues in his own life.


She said "One of the most important things," that a caregiver can do is to ask for help.


Talk about the disease has proven useful for the Miller family, says Rogen.

"Once that you get on the instinct to not talk about, there are many people who are much more favourable that you imagine perhaps," Rogen said.

Low vitamin d levels linked to more aggressive cancers of the breast (HealthDay)

patients with cancer with low levels of vitamin d have more aggressive tumors and poor results, a new study finds.


Experts say that new findings support that many oncologists suspected for a long time.


"He has been suspected that vitamin d is related to the health of breast somehow, even if the particular channel is still unknown,", said Dr. Laurie Kirstein, surgeon of the breast at Beth Israel Medical Center in New York. "Many oncologists already are following levels of vitamin d in their patients with cancer and recommend supplements for low levels," added Kirstein, who was not involved in the new study. "To connect the levels of vitamin d to the aggressiveness of a particular type of breast cancer is an interesting conclusion;" one that should be validated with a controlled trial. ?


In the study, which will be presented Friday at the annual meeting of the American Society of Breast Surgeons, a team of the clinic of the University of Rochester (URMC) followed by 155 women who underwent surgery for cancer between January and September 2010.


The team examined the blood tests which provide levels of vitamin d for all patients in the period of one year before and after surgery. Also analyzed data on relevant patient breast cancer, such as age, race, the stage of cancer diagnosis, status of menopause, the expression of the genes and the State of estrogen and progesterone.


Researchers have found an association between low vitamin D (less than 32 milligrams per milliliter of blood) levels and poor scores on each major biological marker used to predict the outcome of the breast cancer patient.


"The magnitude of the conclusions was somewhat surprising," lead investigator Luke j. Peppone, radio-oncology research assistant professor, said in a press release URMC. "Based on these results, physicians strongly should monitor levels of vitamin d in the patients with breast cancer and correct as necessary."


Another expert said the findings raise a red flag, but a study more may be necessary.


"It seems to increase evidence connecting the levels of vitamin d and breast cancer," said Dr. Sharon M. Rosenbaum Smith, a surgeon breast full breast Center at St. Luke's - Roosevelt Medical Center in New York. "This study certainly shows another link between the two." However, a direct relationship of cause and effect has not been proven. This study certainly suggests that continued optimization of the level of vitamin d a patient can be advantageous. ?


Vitamin d is found in some foods, but humans synthesize most of the nutrients that they need the action of the Sun on exposed skin. Supplements may also stimulate vitamin d levels.


Rochester team said that their study was one of the first to examine the link between levels of vitamin d and breast cancer progression. Previous studies have concentrated on vitamin d deficiency and risk of development of cancer only.


According to the head of the study Peppone, more research is needed to learn more about the biological basis of the association between vitamin d and breast cancer results, but this study shows the importance of checking the levels of vitamin d in patients with breast cancer.


Experts point out that research presented at meetings is considered preliminary until published in a refereed journal.

HIV infection increases the risk of heart failure: study (Reuters)

NEW YORK (Reuters Life!) - Infection by HIV, the virus that causes AIDS, might increase the risk of heart failure even in patients who have heart disease history step, a US study said.


And as of the HIV virus replicates, the risk increases, added to the study, published in the Archives of Internal Medicine.


"Health care providers traditionally believe HIV and its treatment increases the risk of atherosclerotic heart disease," said the senior author Adreel Butt, at the school of the University of Pittsburgh, medicine in Pennsylvania.


"Surprising conclusions of our study was prior association of HIV with heart failure in the absence of coronary artery disease".


The study involved nearly 8 500 adults, with a median age of 48 in two HIV infected subjects and controls.


The HIV group was most probably also infected by the virus of hepatitis C, 31% to 11% and abuse of cocaine - 22 to 16 per cent.


They were also more likely to be smokers, but less likely to have hypertension or diabetes.


In a tracking median of 7.3 years, 286 people developed heart failure. Rate of failure heart per 1,000 person-years, adjusted by age as well as of race and ethnicity, were 7.12 for HIV patients and 4.82 for controls.


After taking account of traditional risk factors, the ratio of risk for heart failure with HIV was 1.81.


In addition, continuous replication of the virus has led to a significantly higher risk of heart failure.


"However, if the replication of HIV is well controlled, then the risk of heart failure is closer to that observed in non-HIV people," Butt said.


The exact mechanism by which HIV infection is linked to heart failure remains uncertain, but possible explanations include the direct effects of HIV infection, antiretroviral treatment leads to an increased risk of coronary heart disease and nutritional deficiencies.


"Our results indicate that HIV is played an important and independent role" Butt and his colleagues wrote.


The message for HIV care providers is clear, though.


"Be on the lookout for signs of heart failure in people infected with HIV, even if there is no history of previous coronary heart disease," Butt told Reuters Health.


"Controlling although HIV can reduce the risk of a heart attack.".

Not all patients with pneumonia need chest radiography (Reuters)

NEW YORK (Reuters Health) - pneumonia patients who are less than 50 years and who do not smoke do not need chest x-rays to look for lung cancer, suggests a new study of the Canada.


The conclusion is contrary to most of the guidelines for the treatment of pneumonia, who say that patients should have the x-rays to exclude the lung cancer as the cause of the pneumonia.


It is also in the recent research suggesting that scans of chest radiation may increase the risk of certain cancers, including breast cancer.


"If you are more than 50 years of age and a smoker, you need a follow-up chest x-ray,"Dr. Eric Mortensen, who has studied the pneumonia and lung cancer, at the University of Texas Health Science Center at San Antonio, told Reuters Health.""


However, "it is important not be exposing people who do not have a radiation risk (lung cancer), has added" said Mortensen, who was not involved in the present study.


Dr. Sumit Majumdar of the University of Alberta in Edmonton and his colleagues followed on 3 400 patients treated for pneumonia in their city between 2000 and 2002.


Patients have an average age of 58, and approximately one in six were smokers.


During the 3 months after that they have been diagnosed with pneumonia, less than half of the patients received an x-ray to check for lung cancer.


Just over 1% of all patients of pneumonia (36 people) have been diagnosed with cancer of the lung, based on an x-ray in these 3 months - which increased by 2.3% (79) with x-rays given over the next 5 years. None of the patients younger than 40 got cancer of the lung during these 5 years of follow-up.


The researchers calculated that if all patients were given a chest x-ray quickly after the treatment of pneumonia, 1.7 per cent of them have been diagnosed with lung cancer. If Chest Physicians limited x-ray patients 50 and older, that a case of lung cancer would have been missed and near 3 percent of chest x-rays have found cancer in the elderly population.


One might think chest x-rays only should be performed on patients with pneumonia 50 years and more to reduce the number of x-ray on people who are very likely to have lung cancerthe authors write in Archives of Internal Medicine.


They add that the costs of an x-ray in Edmonton are approximately $35, so only Imaging patients older than 50 years cost would be $ 1,250 "by detected lung cancer", versus $2 when all patients with pneumonia radiographs.


The guidelines recommend that patients with pneumonia tested for both because lung cancer may be closely related.


"One of the reasons people get pneumonia is because their lungs, draining are not of correctly... because there is a hidden cancer, and it is as a sewer backup", Majumdar told Reuters Health.


But in reality, the results show that lung cancer is very rarely the cause of pneumonia, said.


Mortensen said that additional radiation given by a single x-ray is not much, but might as well be avoided if possible. In addition, he said, when more people who have probably not lung cancer lung x-rays, "We will find things are not really there," leading to more tests unnecessary or treatment even in people who are not cancer.


"We need to really understand which populations are at risk of lung cancer and those who are those that that we should be aiming (x-ray)," Mortensen concluded. "Is added costs, he added the radiation, and if you have not it, you need it.".

Miranda Lambert is having a moment

Miranda Lambert and his trainer of circuit training, lunges and crunches and every morning for 30 minutes of walking.Lambert eat lots of protein to stay energized on the roadLambert and boyfriend Blake Shelton have seven dogs, time for kids "the difficult part is I am a daughter of normal size, and I'm good with that."said Lambert

Miranda Lambert may have forgotten to thank her fiancé, companion of music country star Blake Shelton, when she won her first Grammy this February.


But when we took with the star of 27 years on tour, Blake is top of mind. In fact, indigenous Texas was very happy to talk about everything, since its secrets of energy to how it is more in the form of "I" Advanced swap with Blake earlier this month.


Q: you're now in Evansville, Indiana. Have you ever reach confused on what city you are in?


A: Yes! Usually they write where we are on the set list, because I made the error say ill before. I was like, "Hello, Ohio! And they just looked at me as my head was on fire. [Laughs].


Q: and how do you keep your energy on stage?


A: I eat lots of protein and enough own eating. Junk food dragged you to the bottom. I try not to do anything that is less than two hours before that I'm on stage, because I do not want to be there all proud. I have basically a salad to chicken grilled after the show, and that fills me.


Canstar: 9 low - cal chicken salad recipes


Q: do you have a trainer with you on the road, right?


A: Yes, I wanted to do better and wanted to keep it goes for marriage. We do a lot of training on the circuit, lunges and crunches. And every morning we walk for 30 minutes.


Q: your parents were private eye who heads an agency of the home. This looks like a TV show!


A: it does. But we [at the time], it is just the jobs of my parents. I have been monitoring a lot sounds exciting, but it has never been. If no there was no babysitter, I had to go and my brother and I would be fair lies in the rear and colour for 15 hours during that my mother was watching the House.


Q: you knew what your parents did, exactly?


A: in a way, I had such a normal life. But otherwise, I've seen things that do not see most of the children. Our dinner conversations were not in school and home work; they were on a divorce or child custody cases. When I was young, my parents took to victims of domestic violence, which has been permanently revealing. I had to share my room with a woman and children who had been victims of violence.


Canstar: 8 reasons to family dinner


Q: what is the healthiest thing about your childhood?


A: we had a farm and garden, and for about two years, we have literally lived the Earth. We have raised rabbits and chickens and also had our own pigs which we shot. We did a not really go to the store for what anyone outside milk. My mother would say, "Go select what you want for dinner", and we would go in the garden and whatever vegetables we wanted. It was really old school and truly grandiose.


Q: is it hard slaughter animals who were your pets?


A: dad would give us two rabbits as our pets, or we would have a pig, that we may appoint. They explained only each animal was a pet - some have been providing our family. It sounds strange to other people, but I look at it as there are some animals that feed you and animals that feeds you.


Q: are you a good cook?


A: [Blake and I are] both very well. We have a lot of catfishes, and everyone knows the best way to eat Catfish is fried. I tried to be in good health and bake in the oven once, that was horrible. We ordered a pizza!


Canstar: 13 recipes easy pizza


Q: How did you know that Blake was that?


A: the first day that I met him, I knew that it was really special. We balance each other. He is consistently pleasant, and I am serious. It can make me laugh at any time. Especially when I try to be crazy, he'll go, "we are in a fight." And then I will start to laugh and go, "I guess not now.".


Q: it must understand the pressure of being in the eyes of the public. It no longer sufficient to be just a singer not - you need to look at too. -Is it difficult?


A: absolutely. The more you get, you have to deal with the pressure. The rigid part is I am a daughter of normal size, and I'm going with that. All of these stars are so tiny and they spend their lives trying to be skinny. I want to look at my best, but I am not a model. I am not an actress. I represent the normal girls. It is OK to have a little of the curve. I am pleased of my body. So many girls come up to me and say: "Thanks to be normal," and I am proud of that.


Canstar: Find your feel great weight


Q: the guys you want kids?

A: we have seven dogs, so we'll just take care of them. They are all bailouts and all the crazy - research. Each animal is named after a song or an artist - Delta, Delilah, dear, Jessi and Waylon, Virginia Bluebell, Black Betty. We have so much going on right now, we will wait some time. Dogs are really good birth control!Copyright Health Magazine 2010

Shriver: Impact on women

 father of Maria Shriver, Sargent Shriver, died of Alzheimer's disease in January after receiving a diagnosis in 2003. In his first public remarks on his father since his death, Shriver spoke to Larry King, of his battle against the disease, his thoughts on the research of Alzheimer's disease and why the disease is particularly hard on women. His interview can be seen in its entirety may 1 at 8 p.m. et Sunday on "" a Larry King special, the unthinkable: epidemic of the disease of Alzheimer's. ""


After the diagnosis of his father, Shriver became a vocal advocate for patients, families and caregivers of Alzheimer's disease. It has established a partnership with the Alzheimer's Association published a groundbreaking study called "Alzheimer's in America: the Shriver report on women and Alzheimer's disease," just out in hand.


The report is watched Shriver Alzheimer's disease as a women's disease from the point of view of the patient, family and caregivers. Here is an excerpt of a letter with "" the Shriver report: ""


"I am Maria Shriver, and I am a child of Alzheimer's disease."


This is how I myself am introduced last year when I've testified before the Senate Special Committee on aging. I was there to support the task force on Alzheimer's disease, a panel of Ribbon - blue Congress had accused, at the request of the Association of Alzheimer's disease, develop a plan of action to treat Alzheimer's disease.


Alzheimer's disease is an epidemic. Every minute, or if - in fact, before go you at the end of this page - a person in this country will develop Alzheimer's disease. Millions of people already were officially diagnosed. Millions more are not diagnosed - or diagnosed a form of dementia that can be in reality of Alzheimer's disease. And, with 78 million baby boomers now moving in their years later, the cost of Alzheimer's disease in American society should be $ 20 billion by the year 2050. This is correct--20 billion.


There is no doubt about it. We are in the midst of a national emergency, and we're woefully unprepared.


I was so he in this courtroom packed, sat with the members of the group for the study of Alzheimer's - former House Speaker Newt Gingrich, former Senator Bob Kerrey, former Supreme Court Justice Sandra Day O'Connor (who left the High Court to take care of her husband with Alzheimer's disease) and Larry Butcher, President of care community in Florida Alzheimer's disease (which would lose its month wife later younger onset of Alzheimer's). We all seek this powerful Committee of Congress listening, attention, increase funding and to take on Alzheimer's disease.


I must admit it was something of an experience surreal for me, because the truth is, for many years, it is my father, Sargent Shriver, who would be seated in this Chair, arguing with the Senators to listen, pay attention and the increase in funding. My father was the one who rise to the Hill to testify for his beloved Peace Corps and for all the war on poverty programs he started and fought for, including the head start, Vista, body of employment and Legal Services for the poor. My father was legendary as he worked on Capitol Hill. He knew that each Senator and member of Congress by name. He knew that their careers, their interests, their policies and their soft spots. It was brilliant, idealistic and optimistic official. My father was a bright, a walk - his mind an encyclopedia listening beautifully instrument that has left people in awe and inspired.


At the time. It does not now know I am his daughter, and he does not even know my name. To be honest, it is always very difficult to wrap my mind around this. But so will the reality and the grief of Alzheimer's disease. It is a breathtaking disease - not only for people who get it, but for everyone around them. That is why I am so passionate about flying it.

Patients Beware you surgery on the wrong side

"I'm just beside myself. I have no idea what happened in that operating room," Tasha Gaul says of her son.About 2,700 surgeries are performed each year on the wrong body part or patient"It's serious, it's preventable, and it should never happen," expert saysBe aggressive, repeat your name and birthday, and trust your gut

Early one morning in April, Tasha Gaul and Dale Matlock took their young son, Jesse, to a hospital in Portland, Oregon, for surgery to correct his lazy eye. It was supposed to be an easy procedure: Jesse, who was 3 at the time, wouldn't even have to spend the night at the hospital.


The surgery was indeed quick and simple. The problem was, it was on the wrong eye.


Gaul says she remembers what the surgeon, Dr. Shawn Goodman, said to her as she exited the operating room.


According to Gaul, Goodman told her, "Frankly, I lost my sense of direction, and by the time I realized it was the left eye, I was almost done."


Gaul claims that after Goodman realized her mistake, she performed the surgery on the correct eye.


In a statement to CNN, Goodman's office, Child Eye Care Associates, wrote that she cares very much about all of her patients and wants only the best for them. Because of patient confidentiality (HIPAA), she cannot talk about any patient to the public, the statement said.


I'm just beside myself. I have no idea what happened in that operating room," said Gaul, who'd been taking her son to Goodman for two years before the surgery.


Gaul and her fiancé have contacted Portland attorney Chuck Paulson and plan to sue.


"I feel like we had a right to know the second she realized she was in the wrong eye," Gaul said. "She went into the wrong eye first, and that's why we make a big deal about this."


Harmed in the hospital: Should you sue?


According to a 2006 study looking at the frequency of surgical errors in the United States, each year there could be as many as 2,700 mistakes where a surgery is performed on the wrong body part or the wrong patient. That's about seven per day.


Goodman works in her own private practice but has hospital privileges at Legacy Emanuel Medical Center, where Jesse Matlock underwent surgery. In a statement, Legacy says, "we are working with our operating room staff, and with the private practice physicians who were involved, to identify what happened so we can prevent it from happening again."


Protocols to prevent wrong-site surgeries are good but not infallible


"Not another one." That's the first thought that went through Dr. Kenneth Kizer's head when he learned of what happened to Jesse Matlock.


"It's serious, it's preventable, and it should never happen," he said.


Kizer is the former CEO of the safety advocacy group National Quality Forum and the man who helped coin the term "never events," a list of 28 adverse events -- such as operating on the wrong body part or giving a patient the wrong medication -- that happen in the health care system and put patients at serious risk.


He says efforts to prevent these types of surgical errors have gotten better over the past decade, but there is still room for improvement.


"People underestimate how complex the system is and the number of ways that errors can happen," he said. "There are dozens of doctors that will be involved in a case that goes to an operating room. Every time someone new sees a patient, there's the potential that they'll miss something or get a detail wrong."


Patient safety advocates suggest that hospitals use a checklist. The American Academy of Ophthalmology, for example, has a task force focused on patient safety and provides a checklist of recommendations that physicians should follow before, during and after an procedure on the eye to prevent wrong-site surgeries.


But, sometimes it doesn't happen.


"The checklist process is good, and people have adopted it better than expected, but there are limitations," said Dr. Samuel Seiden, an anesthesiologist and co-author of the 2006 study on surgical errors. "The systems we have in place prevent a lot of these kinds of mistakes, but not all of them."


For instance, Dr. Michael Repka, a spokesman for the American Academy of Ophthalmology, says it is possible for a mark to be covered up by surgical draping. He also says, "if the skin prep is particularly thorough, the indelible ink (used to mark surgical sights) can become less visible. You don't get rid of it completely, but some of it can come off."


Experts say even the best doctors can make mistakes. According to Repka, it is possible for eye surgeons to become disoriented because they're used to examining a patient from in seated position -- a different angle from the operating table. He says ophthalmologists are aware of this, which is why they take preoperative protocol very seriously.


Here are six things you can do to reduce your risk of a wrong-site surgery:


1. Ask, "What are you going to do to ensure that you don't operate on the wrong site?"


Kizer says that asking this question explicitly puts the concern on the doctor's radar. "Patients have to be aggressive sometimes," Kizer said. Also, if someone new is seeing you, this question may help to remind them to review your records and clarify one more time.


2. Request a "time-out" just before anesthesia.


The Joint Commission's Universal Protocol recommends that the operative team take what is called a time-out right before surgery. That's a time when all relevant members of the surgical team stop and communicate to ensure they are all in agreement on what's about to happen.


Diane Pinakiewicz, president of the National Patient Safety Foundation, says patients should consider themselves critical members of the health-care team.


"Patient involvement is one of the keys. It's imperative that they be proactive," she said.


Pinakiewicz suggests that before going under anesthesia, the patient or the patient's caregiver should not be shy about requesting a time-out or asking the head of the surgical team whether they have taken one.


3. Say: "My name is John Smith, and my birthday is January 21, 1976."


Patient advocates say to make sure your name is double- and triple-checked and that prior to surgery, whether you're speaking with the surgeon, the anesthetist or the nurse, make sure everyone involved in your care knows exactly who you are.


My colleague, CNN's senior medical correspondent, Elizabeth Cohen, advises that if your name really is John Smith, you should also include your middle name.


Don't underestimate the fact that patients in the same hospital may have similar names with slightly different spellings. Stating your full name and birthday can help ensure that you aren't confused with another patient.


4. Don't rush through the informed consent form.


Before having surgery, patients fill out a consent form, which details what specifically is being done and the possible risks and complications. Kizer says sometimes patients glaze over the details because they don't like to hear about the horrible things that can happen.


He says this is a missed opportunity to find potential errors that may have made their way that far.


5. Make sure your doctor initials your site.


The American Academy of Orthopaedic Surgeons urges its members to sign their initials directly on the site before surgery. Make sure your surgeon -- not someone else -- does the signing and that it's in the right place. The protocol may vary from hospital to hospital, but the bottom line is that patients should make sure the surgeon clearly marks the proper surgical site before you leave the pre-op area.


6. Trust your gut.


Jesse Matlock's parents said they initially had a bad feeling about how the surgery would go when, on the morning of the procedure, one of the surgical nurses mentioned paperwork that said the little boy would need surgery on one or both eyes.


"There'd been no mention of both eyes until then," Gaul said. "I immediately had this feeling of dread."


Gaul says her fears were allayed when Goodman, in the presence of other members of the surgical team, indicated the proper incision site by drawing several marks, including one about the size of a quarter on the skin above Jesse's right eye. According to Gaul, after the surgery, Goodman told her that one of the nurses preparing Jesse's eye may have covered up the mark.


The hospital is investigating what went wrong during Jesse's eye surgery.


The chief medical officer of Legacy Emanuel Medical Center issued a reminder to its staff immediately after Jesse's operation, informing them of the incident and reminding them of the importance of following appropriate procedures.


The family will not be charged for the surgery, and follow-up care with another provider will be provided at no additional cost.


"We have a commitment to quality and safety, and we take any failure very seriously," the hospital says.


Right now, Jesse's vision is fine, but his mother has noticed a slight lag in his good eye, his left eye, ever since the operation. She says it may be several weeks before they can know for sure.


"With any surgery on your child, you're going to be stressed and worried and want to make sure it happens the way it's supposed to because you're there to protect them," she said.

"I feel now I have to protect my child from these doctors no matter what. You really can't trust anybody."


Stem funding ban lifted

Lifting of the ban on funding stem cell researchNEW: the NIH has invested more than 500 million in stem cell embryonic human researchThe Court of appeals for District of Columbia rules 2 - 1It is a victory for supporters of research funded by the Federal Government of embryonic stem cells

 a Federal Court has given the green light to continue the funding of the administration Obama embryonic stem cell research.


The controversial 2-1 decision that Friday is a victory for supporters of the Federal Government funded by testing for a range of illnesses and diseases.


The Court of appeal of the United States for the District of Columbia has lifted an injunction imposed last year by a federal judge, who said that all embryonic stem cell research at the National Institutes of Health amounted to the destruction of embryos, in violation of the laws of Congress spending.


A law adopted in 1996 Act prohibits the use of public funds in the creation or destruction of human embryos "to" research purposes. Private money had been used to collect lots of U.S.-run Labs developing cells. The current administration had broken with the Bush White House and issued rules in 2009 allowing these cells to be reproduced under controlled conditions and work on them to go forward.


Obama officials were at odds with many members of Congress on the appropriateness of the research NIH cause really the destruction of an embryo, as prohibited by the Act of Wicker Dickey.


Two scientists had filed a lawsuit to block research. But the Panel of three judges found in his 21-page decision, "applicants are unlikely to prevail because Dickey Wicker is ambiguous and the NIH reasonably appears to have found" the law does not preclude research using embryonic stem cells.


The decision does not separate research on adult stem cells, which is eligible under the Federal Act. Applicants have the option to now take their appeal to the Supreme Court of the United States for review. The question at this stage deals only with the lifting of the injunction allowing funding to continue research on embryonic stem cells. Constitutional issues are still debated at the district court level.


The Government has argued that a long list of described by the National Institutes of Health research projects should be set aside if the Court had not acted and granted a stay.


The field of research on embryonic stem cells has been very controversial, because in most cases the research process is to destroy the embryo, usually four or five days, after the deletion of stem cells. These cells are then blank and can become any cell in the body.


Embryonic stem-cell research differs from other types of research on stem cells, which do not need embryos.


Some scientists believe that embryonic stem cells could help treat many diseases and disabled by their potential to develop in many types of different cells in the body.


The case began with a suit against the NIH scientists are opposed to the use of embryonic stem cells, a group seeking adoptive parents of human embryos, created the fertilization in vitro, the Christian Medical Association and other non-profit.


When the injunction was first published by judge Royce Lamberth to August, Ron Stoddart, Executive Director of the Nightlight Christian Adoptions - one of the groups which brought the action for justice - said he supports research of adult stem cells that do not require destroying embryos.


"Often say," why are you opposed to research on stem cells?' and of course our response is, "We are not", "Stoddart said." ""."We are opposed to the destruction of embryos to get embryonic stem cells."


When President George Bush has first approved federal funding in 2001 human embryonic stem cell research, 60 existing lines of stem cells - which have been created prior to August 9, 2001 - qualified for federal funding. Of this number, only 21 were actually usable for scientists. Later, Bush set aside funding.


Given that the rules of the administration of the Obama entered into force, at least total 75 cell lines strains are eligible for federal funding, according to the NIH.


NIH has invested more than 500 million dollars in research of human embryonic stem cells.


Because these embryos are destroyed when stem cells are removed for research, most opponents believe that it is the moral issue.


These scientists said research continued federal funding is necessary, saying that they would have more flexibility to work in laboratories, through Labs and around the world on the latest treatments and breakthroughs. Supporters of embryonic stem cell research say their studies have shown promise treat a range of debilitating conditions, including injury of spinal cord injury, cancer, diabetes and Parkinson's disease.

Push to stimulate more drugs for deadly rare diseases (AP)

WASHINGTON - Every other week, 7-year-old twins Addison and Cassidy Hempel have an experimental medicine injected into their spines in hopes of battling a rare, fatal disease.


And it's their mom who made that possible.


From her home in Reno, Nev., Chris Hempel persuaded scientists to share their research and managed to get the government to sign off on her daughters' unusual experiment. Hempel says getting help to fight a rare disease shouldn't can't be so hard.


But it's a huge challenge to drug company generate interest in the expensive testing of medicines for diseases so rare - like her girls' Niemann-Pick Type C - that the market is only a few hundred or few thousand people a year.


There are treatments for just 200 of the roughly 7,000 rare diseases, illnesses that affect fewer than 200,000 people, often far, far fewer. Yet add those diseases together, and more than 20 million Americans have one.


Now a movement is beginning to spur more rare-disease treatments: The National Institutes of Health this fall will open a center to speed genetic discoveries into usable therapies, doing some of the riskiest early-stage research in hopes companies then will step in.


A new International Rare Diseases Research Consortium is pushing for at least 200 more treatments by 2020, in part by pooling the work of far-flung scientists and families.


Rather than starting from scratch, the Food and Drug Administration is pointing the way for manufacturers to "repurpose" old drugs for new use against rare diseases, publishing a list of those deemed particularly promising.


And bipartisan legislation recently introduced in the Senate, called the Creating Hope Act, would offer drug makers another financial incentive - a voucher promising fast FDA evaluation of their next blockbuster drug in return for developing a therapy for a rare or neglected disease that disproportionately affects children. It's unclear what the prospects for passage are.


"we have to give drug companies a reason to go into this market," says Nancy Goodman of Kids v Cancer, a group pushing the legislation. Her son Jacob died at age 10 from a type of brain cancer that has no good treatment.


"my kids may not be curable, but they are treatable," adds Hempel, the Nevada mom. "Who's going to take this over?"


Pharmaceutical giants are starting to show some new interest in rare diseases, traditionally a niche market for small biotech companies. The practical reason: Blockbusters are drying up, says Dr. Ed Mascioli of Pfizer Inc., the world's largest drug company.


"the industry as a whole has a pipeline problem." "It's increasingly difficult to develop drugs for common diseases," says Mascioli. He heads a separate research unit that Pfizer opened last year to search for medications for some distinctively gene-based rare diseases, such as muscular dystrophy and hereditary emphysema.


Some other companies, including Novartis AG and GlaxoSmithKline PLC, also have begun rare-disease programs.


But NIH Director Dr. Francis Collins says all the activity also reflects a larger promised. "Getting a home run with a rare disease sometimes points you in a direction that will be beneficial for common diseases," he told The Associated Press.


That's Chris Hempel's argument: Niemann-Pick Type C, or NPC, causes cholesterol and other fats to build up to toxic levels inside cells, harming various organs and especially the brain until patients lose the ability to talk, walk and swallow. Only 500 children worldwide are known to have it. purpose a drug that could flush out that build-up, Hempel contends, just might point to a new route to fighting heart disease or Alzheimer's.


For PCNs, Hempel hopes to repurpose cyclodextrin, a sugar-like compound that's already used in numerous products. Purpose by itself, it wasn't deemed to have any drug effects - until scientists at the University of Texas Southwestern Medical Center made the surprise finding that cyclodextrin helped mice with NPC.


When her daughters were diagnosed in late 2007, Hempel desperately searched scientific journals for any hint of a treatment and ran across the Texas research.

What works in mice often fails in people, and it can take years of additional research before animal experiments lead to human studies.

"They don't have years," says Dr. Caroline Hastings of Children's Hospital & Research Center Oakland in California, who leads the twins' cyclodextrin treatment. "they really had nothing to lose."

Subsequent studies in cats at the University of Pennsylvania show promise, too. Hempel found a Florida supplier of cyclodextrin, and worked with Hastings to lead FDA applications for "compassionate use" testing of cyclodextrin in the twins. She even persuaded Johnson & Johnson, which uses cyclodextrin as an inactive ingredient in an anti-fungal medicine, to share proprietary data about the compound's human safety and other issues to address FDA issues.

Addison and Cassidy already have serious symptoms; they'd quit talking. The cyclodextrin was first infused into their bloodstreams in 2009, but says it wasn't penetrating the brain Hempel. So late last year, FDA allowed injections into the spinal fluid, which bathes the brain. It's too soon to know how they'll fare, but the family thinks the girls are more alert, and Hastings says tests show their hearing has improved.

Now, the NIH is planning a formal study of cyclodextrin in a number of NPC patients, to begin within about a year.

Hempel isn't alone in her quest to repurpose common drugs. Consider progeria, a disease that rapidly ages children until they die of a heart attack or stroke, usually before their teens.

Collins' lab at NIH uncovered the gene defect behind progeria research that he says he pursued only because of meeting another mom, Dr. Leslie Gordon, founder of the Progeria Research Foundation, and her son, Sam, who has the disease. Today, clinical trials are under way using a failed cancer drug named lonafarnib that promised to block some of the progeria mutation's effect.

"We're very excited about the opportunities in progeria," says Dr. Gary Gilliland of Merck & Co., which donates the drug and is watching carefully to see if the studies make further worthwhile pursuit.

There are an estimated 150 progeria patients worldwide, but Gordon points to growing evidence that the culprit protein may play a role in the heart disease that comes with regular aging, too.

However, progress is slow. Just because initial research shows a drug looks promising doesn't guarantee broader testing. For example, a National Cancer Institute-funded team is pushing to test a certain class of drugs against a childhood cancer, Ewing's sarcoma. Purpose none of half a dozen manufacturers has yet agreed to provide the drugs, says Dr. Peter Adamson of the Children's Hospital of Philadelphia. The reason, he says: They're not showing enough promise in more common adult cancers.












Common pain relievers may blunt antidepressants (HealthDay)


MONDAY, April 25 (HealthDay News) - Common over-the-counter painkillers such as ibuprofen, aspirin and naproxen may reduce the effectiveness of antidepressants called selective serotonin reuptake inhibitors, or SSRIs, according to a mouse and human study from The Rockefeller University in New York City.


SSRIs - which are the most common antidepressants and are used by millions of people - include such popular drugs as Lexapro, Prozac, Paxil and Zoloft. The potential interaction between these drugs and the painkillers known as nonsteroidal anti-inflammatory drugs (NSAIDs) may be a reason that some people don't respond to SSRIs, the researchers report.


"In one study, we found that anyone who reported use of an anti-inflammatory or analgesic agent had a much poorer treatment outcome compared to people who didn't report any use of NSAIDs," said study lead author Jennifer Warner-Schmidt.


One of the open questions is what dose is needed over what time period to produce this effect, said Warner-Schmidt, a research associate in the university's laboratory of molecular and cellular neuroscience. "until a double-blind real clinical trial is done, we can't say what the dose is [or] what the race is time," she said.


"we may only be looking at people who are taking NSAIDs over a long period of time, but it's not clear," she explained.


In addition, why NSAIDs blunt the effect of SSRIs isn't known, Warner-Schmidt said, adding that "we have some speculative hypotheses we will be exploring in further studies."


Even with these caveats, Warner-Schmidt characterizes the effect of the interaction between these drugs as strong.


"If people out there are having trouble with SSRI efficacy and they happen to be taking anti-inflammatory drugs, they may want to speak with their clinician to evaluate whether they need to continue on the anti-inflammatory drugs, and if so, they may consider changing their antidepressant to a different class of antidepressant""," Warner-Schmidt said.


The report was published in the April 25 online edition of the Proceedings of the National Academy of Sciences.


For their study, the researchers gave mice with and without NSAIDs SSRIs. By looking at how the mice one tasks in sensitive to antidepressants, the researchers found those behaviors inhibited in the mice given NSAIDs.


Warner-Schmidt's team confirmed these findings using data from a previous human study. In that trial, people taking NSAIDs were less likely to have their depressive symptoms relieved by SSRIs than those not taking NSAIDs.


In fact, 54 percent of those not taking these anti-inflammatory painkillers said SSRIs relieved their depressive symptoms, compared with 40 percent of those taking both SSRIs and NSAIDs, Warner-Schmidt said.


In addition to their implications for treating depression, these findings may also be important to Alzheimer's patients, according to lead researcher Nobel Laureate Paul Greengard, the Vincent Astor Professor of the Laboratory of Molecular and Cellular Neuroscience at The Rockefeller University.


"Many elderly individuals suffering from Alzheimer's disease also have arthritic or related diseases and as a consequence are taking both antidepressant and anti-inflammatory medications." "Our results suggest that physicians should carefully balance the advantages and disadvantages of continuing anti-inflammatory therapy in patients being treated with antidepressant medications," he said in university news release.


"This is an important observation that needs to be followed up," said Dr. Charles Nemeroff, the Leonard M. Miller Professor and chairman of the psychiatry and behavioral sciences department at the University of Miami Miller School of Medicine.


"If it is possible that drugs that treat bread in any way antagonize the effects of antidepressants, it's really important to know because of the widespread use of both agents," Nemeroff added, noting that depressed patients with chronic pain are difficult to treat.


The belief has always been that they are difficult to treat because chronic pain wears people down and drives them into depression, but this is a different wrinkle." "this would suggest it may be that medications being used to treat their chronic pain may, in fact, be obviating the effects of antidepressants," he said.


While it is too early to draw definitive clinical findings from this study, Nemeroff thinks doctors should ask their patients if they are taking NSAIDs when prescribing SSRIs.

"If you treat [patients] with an SSRI and they don't respond, maybe we ought to ask them if they are taking high doses of NSAIDs," Nemeroff said. "If they are, we might think about finding another way to treat their pain or inflammation," he said.

Cheaper drug eye turns one as good as more expensive (AP)

By MARILYNN MARCHIONE, AP Medical writer Marilynn Marchione, writer medical Ap - Thu 28 Apr, 5: 22 pm EST

Much cheaper drug proved as well as a sum of $2,000 monthly turned to the treatment of common eye disorder which can lead to blindness, a highly anticipated study has found. It also shows that patients may be treated less often, saving them lots of pain and expense.

The results are expected to lead many physicians and patients to walk away from the more expensive Lucentis and use rather blows $ 50 of Avastin for age-related condition called wet macular degeneration.

Improvement of vision after a year was the same for those given Avastin or Lucentis, 1 200-patient study.

The results are a blow to the Genentech from Roche unit, which sells the two drugs. AVASTIN (ah-VAS-Tin) is a cancer drug that doctors have used for many years to treat the disease of the eyes, even if it is not approved for this purpose. Genentech had developed Lucentis (loo-SEN-tis) specifically for eye disease and won approval for it in 2006. A spokesman for the company, said Thursday that the company did not intend to seek approval to sell Avastin for use of the eye or to lower the price of Lucentis.

Yet, the results are a boon for patients and insurers - especially Medicare - because nothing prevents the use of Avastin cheaper, said of the eye specialists. Doctors who use it for the eye disease require a pharmacist to prepare smaller doses instead of the intravenous injection, it is used for cancer.

"It is always good news for patients when there is more than one option for a condition." This is good news for the country. "Now we have potential for significant savings at a time where the cost of health care is mounted sharply,", said Dr. Paul Sternberg, President of the Vanderbilt Eye Institute.

He had no role in the study, whose results were published online Thursday by the New England Journal of Medicine and will be presented at a Conference of research eye Sunday.

Any person wishing to use Lucentis now will have to justify its cost for insurers and policymakers, Dr. Philip Rosenfeld of Bascom Palmer Eye Institute at the University of Miami wrote in an editorial with the study. Has no connection with Genentech, he consulted for several other companies developing treatments of the eye.

Macular degeneration are treated more than 250,000 Americans each year, especially with Avastin, said Dr. Paul Sieving, Director of the National Institute of the eye, the Federal Agency who has paid for the study. Approximately 1.6 million Americans have advanced macular degeneration and another 7 million are at risk of developing it, he said.

The disease occurs when the abnormal vessel growth blood damages the part of the retina responsible for central vision. AVASTIN and Lucentis aim to a protein that stimulates the growth of blood vessels. They are injected through the white part of the eye into the central cavity. Numbing drops are used and patients usually feel the pressure more pain, Sternberg said.

"The first time that you tell a patient they will have to receive one, they are taken aback and apprehension, but they are remarkably tolerated," he said shots.

In the study, patients received one of four treatments a year: Avastin or Lucentis every four weeks, or two drugs based need according to the response. Those on "need" dosage required four to five shots less than a year as the others.

Improvement of vision was almost identical for each drug. Give two drugs less often produces a little less improvement in vision - two letters less on a graph of the vision of reading something a researcher to a finger on his glasses.

"This is a very small difference," said screening of the Federal Institute of the eyes.

Maureen Maguire at the University of Pennsylvania study leader agreed.

The gift of each drug to the need "is certainly a viable option" that many older patients in spare parts the burden of monthly hits, said.

Undesirable, especially hospitalization, were more frequent among users of Avastin, but many of them were side effects are not thought to be drug-related, and the study is too small to give a clear picture on these.

"We have seen more undesirable when we gave less drug," and don't know what that means, that study co-leader Dr Daniel Martin Cole Eye Institute of the Cleveland Clinic.

No great difference were seen in large problems such as heart attacks, strokes and deaths.

In a statement, said Genentech that prove the benefit of Avastin for the eye disease would take "substantial resources and years of clinical development," and that the interest of patients is better served by exploring new drugs.

"We believe that Lucentis is the most appropriate treatment," because it was designed specifically for use in the eyes, said the Chief of ophthalmology at Genentech, Dr. Anthony Adamis.

Although Genentech sells the two drugs, PDL BioPharma Inc. Gets the payment of royalties on Lucentis and Novartis AG has the exclusive rights on it outside the United States.

___

Online:

Journal: http://www.nejm.org

Blacks more willing to spend for cancer care (AP)

ATLANTA - blacks and other minorities with cancer are more likely than whites to say that they spent all that they have on aggressive treatment that might extend their lives, a study found.

Researchers don't know why this is the case and not asked pas, but some believe it may reflect differences in beliefs about miracles, distrust of doctors among the minorities, and may be a poor understanding of end-of life how ugly and painful.

Approximately 80 percent of blacks said they were ready to use all the money to extend their lives, compared to 72% Asian, 69% of Hispanics and 54% of whites.

"It's interesting how far patients minority, particularly black patients, are ready to go to extend their life," said Ellen McCarthy, a researcher at Harvard University who has studied the racial disparities in cancer care but was not involved in the new study.

The findings, published online Tuesday by the journal Cancer was based on telephone surveys more of 4,100 persons newly diagnosed lung and colon cancer. About 17% of patients in cancer of the colon and 31 per cent of lung cancer patients were in the more advanced stages of their illness.

These two cancers were chosen because they are common and lethal when diagnosed in the later stages. Patients with cancer of the breast or prostate - the most common types among women and men, respectively - were not included, and it was unknown if their attitudes differed.

The cost of cancer care have exploded in recent years, with many treatments at a price of $100,000 or more adding sometimes only a few months of life.

Last days under aggressive treatment may be sad. Patients may have tubes in the nose and throat and be unable to eat or speak. They may be in pain or barely coherent.

"Some believe to be living in all circumstances is an absolute good, which suggests a underappreciation of loads and overappreciation care benefits extend life," said Holly Prigerson, another researcher from Harvard who heads a centre of Dana-Farber Cancer Institute that studies the social and psychological influences on cancer care.

The study asked: you want treatment extended your life as long as possible, even if it caused go you broke? Or you would opt for cheaper treatment which has not kept you live so long?

The researchers gave no aggressive example of what care - surgery or chemotherapy, example could - and did not specify how much more the patient might live.

The results revealed the racial differences even when other factors were taken into account.

For example, people with spouses and dependent children were generally less favourable than the single exhaust their financial resources for their care. But among these family people, blacks were more ready to go broken.

The same schema racial place regardless of how the patients were, their income and savings, the age, time since diagnosis and how long they thought they had left to live.

"It was surprising," said lead author Michelle Martin of the University of Birmingham in Alabama.

The study found black had more often an attitude "try". This seems to contradict previous studies that have indicated Blacks have a greater distrust of the medical system.

But mistrust might still be a factor. Perhaps a greater proportion of minorities worried that doctors could withhold care of them, and therefore they might seek the more aggressive, available options, McCarthy said.

Minorities tend to be diagnosed at later stages of cancer than whites. At least a study of patients with advanced cancer found that blacks who wanted intensive end of life care were less likely to receive only the whites with the same preference.

Faith may be another factor. The study did not assess participants how religious were, but other studies have shown that very ardent people tend to want and get treatment to prolong life, said Prigerson.

"Assert many religious patients, ' there is a higher authority than my physician.". God, not my doctors, decides if my time or not. "These patients believe that it is a demonstration of their faith to keep for as long possible to expect the granting of a miraculous healing of life,"she said."

Diagnosis of Alzheimer's disease redefined

Alzheimer's disease begins long before family and friends notice differences in the patient's memory and behavior, doctors who treat the condition said Monday. By the time an official diagnosis is made, the person's function is usually significantly impaired and treatment rarely helps.


Doctors are suggesting a redefinition of Alzheimer's that would include even mild memory and behavioral symptoms. Disease experts expect an increase in the number of patients receiving the Alzheimer's diagnosis as a result of the change.


The idea, proposed by the Alzheimer's Association and the National Institutes of Health, would define Alzheimer's as a "spectrum" disease, creating three internships ranging from lesser to greater severity in hopes that the devastating neurological condition could be detected earlier.


In the U.S., 5.4 million people have an Alzheimer's diagnosis. By 2050, that number is expected to more than triple.


The aim of identifying the disease is to get patients earlier in the pipeline for research for future treatment. When the disease isn't identified until later in its progression, patients are more effective and treatments are even less impaired, doctors said. Current therapies usually don't make much difference, doctors acknowledged in a media briefing Monday.


Study: Popular Alzheimer's ineffective drug for mild cases


"It's critically important when we have effective drugs to intervene as quickly as possible," said Marilyn Albert, professor of neurology at Johns Hopkins University School of Medicine, who helped formulate the new guidelines. "there could be drugs available now, but we re using them too late in the disease course."


"the goal in the field is to find people earlier, so when new treatments are developed, we can use them."


The new guidelines appear Tuesday in the journal Alzheimer's & Dementia.


The original criteria for Alzheimer s disease, written in 1984, defined the disease in a single stage and assumed people who didn't have symptoms did not have the disease. This original definition addressed only later stages of the disease, when it ravages the patient's ability to function.


When Alzheimer's turns violent


The newly expanded stages of Alzheimer's are meant to cover the full spectrum of the disease as it first over the years.


"For people working with Alzheimer's patients day-to-day, it doesn't make a huge difference in practice right now," said Dr. Neil Kremen, unit chief at the Geriatric Psychiatry Inpatient Unit at Zucker Hillside Hospital in New York.


Most doctors working with Alzheimer's have already accepted that the disease is a progression.


"people who work in the field have known this," he said about various stages of Alzheimer's. "it has been accepted." It was never codified into a standard guideline. "In some sense, it's the formalization of things that people already know."


The courses have been divided into preclinical Alzheimer's, mild cognitive impairment and dementia.


First stage: Preclinical Alzheimer's disease


This internship is for research purposes only and will have no effect in your doctor's office.


The idea is that patients could be developing Alzheimer's, even when they are free of cognitive or memory problems.


This course is to help researchers determine whether there is a biological change caused by Alzheimer's that can be detected through blood, spinal fluid test or neuroimaging. Right now, there is no test that accurately predict whether a person will develop Alzheimer's disease.


With love and fear, Alzheimer's youngest caregivers watch over parents


While studies show that Alzheimer's patients experience changes in the brain - the buildup of amyloid protein tangles and nerve cell changes - it is unknown whether this means an inevitable progression to Alzheimer's dementia.


"Changes in their brain can be measured, but we can't predict for sure whether they're going to have the clinical disease," said Dr. Creighton Phelps, director of the Alzheimer's Disease Centers Program of the National Institutes of Health.


These tests are used only in research settings.


Scientists are working to develop a more definitive test or a scan to determine Alzheimer's risk.


Second stage: Mild cognitive impairment (MCI)


Long before a person gets an Alzheimer's diagnosis, he or she may show small changes in memory, behavior and thinking. This is called mild cognitive impairment.


Aging work force means dementia on the job could rise


While it does not cripple a person's ability to function throughout the day, these differences are often noticed by friends and family members.


Some patients in this stage are already observed by their doctors as "probable Alzheimer's."


This is a gray area because not all memory problems are Alzheimer's - related. Cognitive difficulties could stem from other factors such as a drug's side effects or vascular disease.


This stage could be used in specialized Alzheimer's clinics. A specialist might determine that the cognitive problems are caused by underlying Alzheimer's disease after a comprehensive exam, based on the disease process and symptoms, said Dr. John c. Morris, director and principal investigator of the Alzheimer's Disease Research Center at the Washington University School of Medicine.


But there are no blood or medical tests available in doctors' offices to confirm whether the mild cognitive impairment is because of Alzheimer's.


Third stage: because of Alzheimer's Dementia


This is the stage when memory, thinking and behavioral symptoms have become so damaging that the patient's ability to function is hindered.


The disease is not solely restricted to memory problems. The new guidelines include other symptoms such as difficulty finding words, visual and spatial problems, impaired reasoning and judgment.


This is the stage that people are most familiar with. The patient eventually becomes unable to carry out basic daily tasks - eating, bathroom-related functions and is fully dependent on others for basic care.


The purpose of setting out these updated stages of Alzheimer's is aimed at the future, Creighton said, to "define a research strategy for people who may be at risk for Alzheimer's."