Could coffee men risk low for Prostate Cancer? (HealthDay)

men who drink at least six or more cups of coffee a day may be cutting their risk of prostate cancer advanced of 60 per cent, suggests new research.

This is the first study important research specifically on the relationship between coffee and cancer of the prostate metastatic, researcher Kathryn senior, Wilson said. "It is an interesting finding, because there are not many of modifiable risk factors for prostate cancer."

A definite causal link is still far from proven, experts say just how coffee may help thwart prostate cancer is not clear.

"There is many compounds in coffee have different biological effects." It is an important source of antioxidants and may have anticancer effects, said Wilson, research in epidemiology at the Harvard School of Public Health, Boston. "Also, coffee appears to have effects on insulin and has been associated with a lower risk of diabetes type 2.". In addition, the insulin is supposed to play a role in many types of cancers, including prostate cancer. ?

Composed of coffee also have an impact on levels of sex hormones, according to the study of.

But at the present time, the point of finding only an association between a love of "java" and a better santée of the prostate. A study more is needed to confirm the results and if a biological explanation for the phenomenon exists, said Wilson.

The bottom line, she said: "it is probably too early to tell someone that [he or she] should go outside and start drinking coffee just because of this study.".

The report was published in the online edition of the journal of the National Cancer Institute on May 17.

Prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer death in men in the United States. In the United States, it affects one in six men in their lives. More than 2 million Americans and 16 million men around the world are the survivors of prostate cancer, say researchers.

The study, the Wilson team collected data on nearly 48,000 men who took part in the health professionals follow-up study and their follow up to 2008. Every four years since 1986 these men reported on how much coffee that they drank.

The researchers then calculated the risk of prostate cancer to the amount of coffee drunk. During the period of the study, they have identified 5035 case of prostate cancer, of which 642 were fatal cases in which the cancer was metastatic, which means that it had spread beyond the original site.

The Harvard team has found that drinking six or more cups of coffee per day was associated with a nearly 20% less risk of developing cancer of the prostate, with those who do step drink coffee.

In addition, the chances of developing the most lethal and advanced prostate cancer has decreased by 60%, compared with men who have refrained from coffee - a statistically significant parent and "substantially lower" risk, according to researchers.

Even men who drank less coffee - one to three cups per day - had a 30 percent lower risk of developing cancer of the prostate lethal, and risk reduction have been observed if the men drank caffeinated coffee decaffeinatedWilson group added.

After taking into account other lifestyle factors, such as age, smoking, obesity and exercise, the decline in the relative risk of prostate cancer remains, they said.

"This adds to the evidence of a variety of coffee diseases does not appear to be harmful," said Wilson. "It has been demonstrated quite regularly, to be associated with a lower risk of Parkinson's disease, type 2 diabetes and cancer of the liver." This is an another potential more coffee.

The study was limited by the prevalence and the absence of data on the consumption of coffee of previous periods of life among men, the researchers noted.

The finding comes on the heels of a study published last week which found that women who drank five or more cups of coffee per day has seen a significant decrease in their risk for a particularly aggressive form of breast tumours. The Swedish study, a team at the Karolinska Institute in Stockholm, was published in Breast Cancer Research.

Commenting on the results of the Harvard team, Eric Jacobs, strategic Director of Pharmacoepidemiology at the American Cancer Society, it calls a large, well designed study. But he stressed that, until now, it remains the only study to show such a link.

"It is premature to conclude that drinking coffee may help prevent fatal prostate cancer," he said. "We do, however, know that smoking and obesity are associated with a higher risk of prostate cancer fatal, and the death of many other diseases." "It is fine enjoy a nice cup of coffee, but avoiding smoking and maintaining a healthy weight are among the safest to stay in good health means".

Tonsils ablation could cure bedwetting in some children with apnea sleep

 half of the children with sleep apnea who wet the bed could stop their UI if their tonsils or sleep is removed, new research suggests.

Obstructive apnea (OSA) sleep is marked by interruptions of respiration; during his sleep It is common among children with enlarged tonsils or sleep. Exactly how the results in the bedwetting sleep apnea is not fully understood, but hormonal changes may play a role.

However, half of the 417 children in this latest study, which had the sleep apnea and who were arrested bedwetters bed wetting after they had their tonsils or deleted sleep. In the study, the children were aged 5 to 18 years and were followed for only less than a year after their surgery on average.

Those that did not prevent bed wetting after surgery were more likely to be born prematurely, be men, being obese or have a family history of bedwetting, the investigators noted. Premature birth was the best index prediction of continuous UI after surgery.

"If they have not seen an ear, ENT specialist, see one to see if the child anchored bed OSA that can be cured by the tonsils or Mucoepidermoid removal," said study author Dr. Yegappan Lakshmanan, head of the Pediatric Urology of the Michigan children's Hospital, in Detroit.

The findings were presented Monday at the annual meeting of the American Urological Association (AUA), in Washington, D.C. presented research at medical meetings should be regarded as preliminary in until it was published in a peer medical journal.

There are many other causes of bedwetting, said Lakshmanan. "5 To 7 million children are bedwetters, and causes of the fall into three main groups: issues of the bladder, problems related to sleep, and kidneys,"he explained.""Children in this study wet the bed sleep-related problems. ?

Then why were not all cure? "Nocturnal enuresis is multifactor even these groups and that we should be able to determine the cause of all children", said Lakshmanan.

"There are several possible causes of bedwetting, and sleep apnea is clearly one of them," said Dr. Lane s. Palmer, Chief of Pediatric Urology Medical Center the MCH Cohen again of Hyde Park, New York

"There are positive effects of this surgery tonsils - or adenoid-deletion, but I don't know that I leap tonsils or sleep out of my child as a primary treatment of bedwetting," he said. "Children with sleep apnea and UI should see an otorhinolaryngologist first."

"This study really points to the fact that children who have other sleep problems should be considered for UI because all that is fall sleep at night can lead to bedwetting," said the spokesman for the AAU Dr. Anthony Atalaa urologist at Wake Forest University in Winston - SalemN BW.

"If a child bedwetting, pay attention to their sleep habits and to observe, while they are asleep, and you can see if they breathe at a steady pace and otherwise, seek additional aid," said Atala.

Children with sleep apnea can be difficult to rouse, which can cause bedwetting, said Dr. Dennis Kitsko, an Otolaryngologist at children's Hospital of Pittsburgh. "But not all children with sleep apnea will wet the bed, and not all are bedwetter will sleep apnea".

Still, "snoring in children is abnormal, said Dr. Linda Dahl, an ear doctor ENT at Lenox Hill Hospital in New York." "" "Broaden children snore because their tonsils and sleep, and they have other behaviors that go with apnea sleep, including bedwetting, eventually", she explained.

"There are many ancillary benefits that you may not attribute to the removal of tonsils grand and sleep, as stop bedwetting," Dahl said.

The Health Council: could your child be constipated?

children can become constipated since a practice experts call "retained stool" - deliberately not to go to the bathroom because of embarrassment, the fear of an unpleasant experience, or a desire not to interrupt playtime.

National Information Center for digestive diseases, says parents should be aware of these warning signs that a child may be constipated:

With little frequent stool.Display of posture indicating the child takes on a stool, including tighten the buttocks or toggle back and forth.Who complains of pain or cramping in the belly.Difficulty in passing stool.Passing stool that are big, dry or hard.Find saddles in underwear for your child.

"superdrug" could fight both HIV and malaria (LiveScience.com)

HIV, the pandemic virus that causes AIDS, kills 2 million people each year worldwide. Malaria, a ubiquitous parasite spread by mosquitoes, infects 225 million people and kills 781,000 each year. The former disease ravaging our species since the spread we monkeys a mere 40 years; It has been our enemy for so long, our bodies have evolved means to fight.

The two killers, new and old, were in fact some molecular similarities. This fact - and some new research - a single "superdrug" could soon fight both.

This drug is inhibitory protease of HIV, a drug which scientists designed specifically for the treatment of HIV by preventing the deadly virus to build its proteins correctly. "HIV protease inhibitors are now in clinical use and are a leading HIV drug, said Photini Sinnis, responsible of the laboratory of medical parasitology Langone NYU Medical Center." They completely changed the face of the treatment of HIV in recent years. People taking these drugs die of AIDS years. ?

Proteases are enzymes that cut the proteins in their correct forms, enabling them to become active. HIV protease inhibitors stop HIV in its tracks by one of its protease enzymes prevents to do the work. Without the work of the protease of HIV proteins remain cut off and inactive, and HIV units, called virions, can assemble to new virions. The body has natural mechanisms for the murder of virions HIV, but it can kill only so many at once. prevent continuous replication virus population of cells HIV at a level that can manage the body.

Two birds, one stone

Over the past few years, several groups of research (including the Sinnis group) have noticed a positive side-effect surprising specific HIV protease inhibitors. "We are seeing that drugs have anti-malarial properties," Sinnis said little mysteries of life, a sister site to LiveScience.

Researchers believe that closed HIV protease inhibitors a protease present in malaria parasites as they do to HIV protease. The Sinnis Group found that anti-HIV drugs prevent the parasite to reproduce in mice.

No human trials have been carried out, but the first results in mice already have researchers in HIV advocating the exclusive use of protease inhibitors for the treatment of HIV in Africa. "In Africa, where the duplication of HIV and malaria a lot, HIV drugs we use should be the protease inhibitors," Sinnis said. "" "". While they would have the additional advantage of inhibition of malaria infection. ?

At the moment, protease inhibitors are useful for fighting malaria in people who already have HIV. They are more toxic than many drugs used to fight against malaria in itself and therefore would not be given to a person just to treat malaria. But if protease inhibitors can be adjusted to be less toxic, they could be viable as a stand-alone antimalarial drug. And when this happens, it will be welcome weapon against the disease: because malaria is changing rapidly immunity to malaria drugs, the news is still desperately needed.

However, to develop a stand-alone anti-malaria drug based on anti-HIV drugs, specific protease in malaria which gets targeted by HIV protease inhibitors must first be found. "If we could find the target protease, we might develop medicines which are better targeting, without toxicity," said Sinnis.

Closing in on the target

Until now, scientists are are reduced to the class of proteases that can contain the protease targets, but they have not found the specific. Because malaria complex life cycle and unusual genome, "it is very difficult to express proteins of malaria [including protease] in the laboratory", Sinnis explained. This makes experiments on slow continuous malaria proteases.

But the answer may be just to arrive. In an article in the may issue of the journal of the Federation of American Societies for Experimental Biology (FASEB), Colin Berry and his colleagues at Cardiff University in England report after finding a protease inhibited HIV protease inhibitor in the Leishmania parasitea relative of malaria. Although protease, called Ddi 1, has not been identified in malaria, group of Berry and others believe that he could be the target protease that everyone has been seeking.

"Our results indicate that Ddi1 proteins are targets of HIV [protease] inhibitors and indicate the Leishmania Ddi1 as the likely target of these drugs and a potential target for antiparasitic treatment", Berry et al. write in their paper. "[By] identifying the responsible protein, we want exploit this weakness in the parasite to develop new and effective therapeutic products against these devastating diseases," they said in a press release.

"[Berry et al.] are suggesting that maybe what they have found in Leishmania may be relevant for malaria." And it is true - it might be, "said Sinnis." "" Paper certainly gives hope and ideas in terms of finding the target in malaria parasites. ?

And when is found, wonder HIV drug can be redesigned to work wonders against malaria for example.